Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 18569..19091 Replicon plasmid unnamed1
Accession NZ_CP024467
Organism Shigella dysenteriae strain BU53M1

Toxin (Protein)


Gene name relE Uniprot ID D0QMR1
Locus tag CPZ97_RS24350 Protein ID WP_000220561.1
Coordinates 18810..19091 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag CPZ97_RS24345 Protein ID WP_000121743.1
Coordinates 18569..18820 (+) Length 84 a.a.

Genomic Context

CPZ97_RS24315CPZ97_RS24345CPZ97_RS24350CPZ97_RS24355CPZ97_RS24360CPZ97_RS24365CPZ97_RS24370CPZ97_RS24375CPZ97_RS24380CPZ97_RS24385CPZ97_RS28085CPZ97_RS24390CPZ97_RS24395CPZ97_RS24320CPZ97_RS24325CPZ97_RS24330CPZ97_RS24335
Location: 13715..14692 (978 bp)
Type: Others
Protein ID: WP_073559672.1
Location: 18569..18820 (252 bp)
Type: Antitoxin
Protein ID: WP_000121743.1
Location: 18810..19091 (282 bp)
Type: Toxin
Protein ID: WP_000220561.1
Location: 19237..19560 (324 bp)
Type: Others
Protein ID: WP_001181905.1
Location: 19608..19853 (246 bp)
Type: Others
Protein ID: WP_052909233.1
Location: 19843..20058 (216 bp)
Type: Others
Protein ID: WP_001180116.1
Location: 20151..20480 (330 bp)
Type: Others
Protein ID: WP_000866648.1
Location: 20523..20702 (180 bp)
Type: Others
Protein ID: WP_072104066.1
Location: 20724..20921 (198 bp)
Type: Others
Protein ID: WP_001675595.1
Location: 20934..21206 (273 bp)
Type: Others
Protein ID: WP_000160399.1
Location: 21463..21537 (75 bp)
Type: Others
Protein ID: Protein_26
Location: 21532..22077 (546 bp)
Type: Others
Protein ID: WP_000757693.1
Location: 22080..23246 (1167 bp)
Type: Others
Protein ID: WP_052909232.1
Location: 14689..15114 (426 bp)
Type: Others
Protein ID: WP_000202958.1
Location: 15185..15628 (444 bp)
Type: Others
Protein ID: WP_001074379.1
Location: 15632..16474 (843 bp)
Type: Others
Protein ID: WP_073559670.1
Location: 16495..17334 (840 bp)
Type: Others
Protein ID: WP_001352874.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CPZ97_RS2431513715..14692+978WP_073559672.1hypothetical protein-
CPZ97_RS2432014689..15114-426WP_000202958.1hypothetical protein-
CPZ97_RS2432515185..15628-444WP_001074379.1hypothetical protein-
CPZ97_RS2433015632..16474-843WP_073559670.1replication initiation protein-
CPZ97_RS2433516495..17334-840WP_001352874.1replication initiation protein-
CPZ97_RS2434518569..18820+252WP_000121743.1plasmid stabilization proteinAntitoxin
CPZ97_RS2435018810..19091+282WP_000220561.1type II toxin-antitoxin system RelE/ParE family toxinToxin
CPZ97_RS2435519237..19560+324WP_001181905.1hypothetical protein-
CPZ97_RS2436019608..19853+246WP_052909233.1hypothetical protein-
CPZ97_RS2436519843..20058+216WP_001180116.1hypothetical protein-
CPZ97_RS2437020151..20480+330WP_000866648.1hypothetical protein-
CPZ97_RS2437520523..20702+180WP_072104066.1hypothetical protein-
CPZ97_RS2438020724..20921+198WP_001675595.1hypothetical protein-
CPZ97_RS2438520934..21206+273WP_000160399.1hypothetical protein-
CPZ97_RS2808521463..21537+75Protein_26DNA distortion polypeptide 3-
CPZ97_RS2439021532..22077+546WP_000757693.1hypothetical protein-
CPZ97_RS2439522080..23246+1167WP_052909232.1relaxase/mobilization nuclease domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmidcatA1 / blaTEM-1D-1..5499354993


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11023.86 Da        Isoelectric Point: 10.5938

>T87699 WP_000220561.1 NZ_CP024467:18810-19091 [Shigella dysenteriae]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADMR

Download         Length: 282 bp

>T87699 NZ_CP024467:18810-19091 [Shigella dysenteriae]
ATGACCTATGAACTGGCTTTTGACCGCAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAACTGGCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATCA
AACTTCGTGCATCTGGCTACAGACTTGTATATCAAGTCATTGATGAGAAAGTTGTTTTACTCGTTATTGCTGTTGGAAGA
AGGGAAAGCAGCGAAGTTTATCAGATTGCAGATATGCGCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT87699 WP_000121743.1 NZ_CP024467:18569-18820 [Shigella dysenteriae]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp

>AT87699 NZ_CP024467:18569-18820 [Shigella dysenteriae]
ATGAGCTATCAAATTCTGACAACCACAGCGGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACCGTAGCTGAAGG
TGAAGGGGACGCTGTTGCGATCCTGAACCGAAACGAACCGGCGTTCTATTGCGTTCCACCAAAACTTTACGCCTACTATC
GGGAACTCGCTGAAGATGCTGAGTTAAACGCTGTTGCTGATGAGCGCATGAAAAACCCGGAAATTGTGAAGGTTAACCTG
GATGACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A3S5I302

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A3S5I301

References