Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4146589..4147184 Replicon chromosome
Accession NZ_CP024466
Organism Shigella dysenteriae strain BU53M1

Toxin (Protein)


Gene name chpB Uniprot ID U9XNP6
Locus tag CPZ97_RS22785 Protein ID WP_000239577.1
Coordinates 4146834..4147184 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID A0A2X2I2M3
Locus tag CPZ97_RS22780 Protein ID WP_001223211.1
Coordinates 4146589..4146840 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CPZ97_RS22770 4142254..4146033 + 3780 WP_000060952.1 autotransporter assembly complex protein TamB -
CPZ97_RS22775 4146036..4146377 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
CPZ97_RS22780 4146589..4146840 + 252 WP_001223211.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
CPZ97_RS22785 4146834..4147184 + 351 WP_000239577.1 endoribonuclease toxin ChpB Toxin
CPZ97_RS22790 4147261..4147791 - 531 WP_000055075.1 inorganic diphosphatase -
CPZ97_RS22795 4148101..4148601 + 501 Protein_4289 galactofuranose ABC transporter substrate-binding protein YtfQ -
CPZ97_RS22805 4149368..4150453 + 1086 Protein_4291 cadaverine/lysine antiporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

Antitoxin PemI-like

(1-83)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12492.40 Da        Isoelectric Point: 5.5572

>T87698 WP_000239577.1 NZ_CP024466:4146834-4147184 [Shigella dysenteriae]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLHARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T87698 NZ_CP024466:4146834-4147184 [Shigella dysenteriae]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTTGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACACGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9315.64 Da        Isoelectric Point: 4.4201

>AT87698 WP_001223211.1 NZ_CP024466:4146589-4146840 [Shigella dysenteriae]
MRITIKRWGNSAGMVIPNVVMKELNLWPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT87698 NZ_CP024466:4146589-4146840 [Shigella dysenteriae]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCTAATGTTGTGATGAAAGAACTTAACTTATG
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCTACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XNP6

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2I2M3

References