Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 3347891..3348645 Replicon chromosome
Accession NZ_CP024466
Organism Shigella dysenteriae strain BU53M1

Toxin (Protein)


Gene name ataT Uniprot ID Q32AN3
Locus tag CPZ97_RS18540 Protein ID WP_000513068.1
Coordinates 3347891..3348376 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A2X2KZA0
Locus tag CPZ97_RS18545 Protein ID WP_000801913.1
Coordinates 3348367..3348645 (-) Length 93 a.a.

Genomic Context

CPZ97_RS18510CPZ97_RS18515CPZ97_RS18520CPZ97_RS18530CPZ97_RS18535CPZ97_RS18525CPZ97_RS18540CPZ97_RS18545CPZ97_RS18550
Location: 3343842..3344168 (327 bp)
Type: Others
Protein ID: WP_000371932.1
Location: 3344213..3345043 (831 bp)
Type: Others
Protein ID: WP_000928722.1
Location: 3345060..3345818 (759 bp)
Type: Others
Protein ID: WP_000815099.1
Location: 3346309..3346809 (501 bp)
Type: Others
Protein ID: Protein_3511
Location: 3346813..3347841 (1029 bp)
Type: Others
Protein ID: WP_024259430.1
Location: 3345800..3346309 (510 bp)
Type: Others
Protein ID: Protein_3510
Location: 3347891..3348376 (486 bp)
Type: Toxin
Protein ID: WP_000513068.1
Location: 3348367..3348645 (279 bp)
Type: Antitoxin
Protein ID: WP_000801913.1
Location: 3348712..3351411 (2700 bp)
Type: Others
Protein ID: WP_134802126.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CPZ97_RS185103343842..3344168+327WP_000371932.1thiosulfate sulfurtransferase GlpE-
CPZ97_RS185153344213..3345043+831WP_000928722.1rhomboid family intramembrane serine protease GlpG-
CPZ97_RS185203345060..3345818+759WP_000815099.1DeoR/GlpR family transcriptional regulator-
CPZ97_RS185253345800..3346309-510Protein_3510DNA-binding transcriptional regulator RtcR-
CPZ97_RS185303346309..3346809+501Protein_3511RNA-splicing ligase RtcB-
CPZ97_RS185353346813..3347841+1029WP_024259430.1RNA 3'-terminal phosphate cyclase-
CPZ97_RS185403347891..3348376-486WP_000513068.1GNAT family N-acetyltransferaseToxin
CPZ97_RS185453348367..3348645-279WP_000801913.1DUF1778 domain-containing proteinAntitoxin
CPZ97_RS185503348712..3351411-2700WP_134802126.1HTH-type transcriptional regulator MalT-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--3333423..337584142418


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-143)

Antitoxin

Vibrio phage ICP1, Orf50

(2-92)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17631.53 Da        Isoelectric Point: 9.1197

>T87697 WP_000513068.1 NZ_CP024466:c3348376-3347891 [Shigella dysenteriae]
MGITAPTPLTSEHNLADFCCSDHGMNEWLKKKALKNHSSGLSRVYVICIANTRQVIGYYCLSTGSIQRNLAPGAMRHNAP
ESLPVVVLGRLAIDQAWAGKGLGVALLKDAVYRTMSIAQQVGVRALIVHALDDSVRNFYLKYAFVPSPFQSLTLLYPITL
E

Download         Length: 486 bp

>T87697 NZ_CP024466:c3348376-3347891 [Shigella dysenteriae]
ATGGGAATAACGGCTCCTACTCCCCTAACGTCTGAACATAATCTGGCTGACTTTTGCTGTTCCGATCACGGGATGAATGA
ATGGCTAAAAAAGAAAGCATTAAAAAATCACAGCTCCGGTCTGTCTCGTGTTTACGTTATCTGTATTGCCAATACCCGCC
AGGTAATCGGCTATTACTGCCTTTCTACAGGCAGTATTCAACGTAATTTGGCCCCTGGAGCCATGCGACATAATGCTCCC
GAATCGTTGCCTGTTGTCGTATTAGGCAGACTGGCAATTGATCAAGCCTGGGCAGGTAAAGGGTTGGGCGTCGCATTGTT
GAAAGATGCAGTCTATCGCACAATGTCCATAGCTCAACAGGTAGGGGTTCGTGCGCTCATTGTTCATGCCTTAGACGATT
CAGTACGCAATTTCTATCTGAAGTATGCCTTTGTACCTTCACCATTCCAGTCACTTACCTTACTGTATCCCATTACTCTG
GAGTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10449.00 Da        Isoelectric Point: 4.6336

>AT87697 WP_000801913.1 NZ_CP024466:c3348645-3348367 [Shigella dysenteriae]
MKPESKEAPINIRAKASQRDLIDMAANLVAKSRTDFMLDAACREAQDILLDQRLFILDDEQYDAFLAALDAPITAERQVK
INALMNRKSPWE

Download         Length: 279 bp

>AT87697 NZ_CP024466:c3348645-3348367 [Shigella dysenteriae]
ATGAAACCGGAAAGCAAAGAAGCGCCAATCAATATCAGAGCGAAAGCCTCACAGCGTGACCTGATTGATATGGCAGCGAA
TCTGGTCGCAAAATCGCGCACTGATTTTATGCTGGATGCCGCATGCCGTGAAGCGCAAGACATCTTATTAGATCAACGAC
TATTCATCCTTGATGACGAGCAATACGATGCGTTTCTCGCTGCCCTGGACGCCCCCATCACTGCTGAGCGTCAGGTCAAA
ATTAACGCGTTGATGAATCGTAAATCGCCATGGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A090ND96

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A2X2KZA0

References