Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 896939..897737 | Replicon | chromosome |
| Accession | NZ_CP024466 | ||
| Organism | Shigella dysenteriae strain BU53M1 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | Q32HN1 |
| Locus tag | CPZ97_RS04835 | Protein ID | WP_001094433.1 |
| Coordinates | 896939..897313 (-) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | Q32HN0 |
| Locus tag | CPZ97_RS04840 | Protein ID | WP_001285603.1 |
| Coordinates | 897360..897737 (-) | Length | 126 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CPZ97_RS04800 | 892524..893078 | - | 555 | WP_001001927.1 | molecular chaperone YcdY | - |
| CPZ97_RS04805 | 893102..893839 | - | 738 | WP_000283663.1 | zinc-binding phosphatase | - |
| CPZ97_RS04810 | 893894..894832 | - | 939 | WP_000351336.1 | glyoxylate/hydroxypyruvate reductase GhrA | - |
| CPZ97_RS04820 | 895303..896145 | - | 843 | WP_005020348.1 | DUF4942 domain-containing protein | - |
| CPZ97_RS04825 | 896242..896439 | - | 198 | WP_000839257.1 | DUF957 domain-containing protein | - |
| CPZ97_RS04830 | 896451..896942 | - | 492 | WP_000976859.1 | hypothetical protein | - |
| CPZ97_RS04835 | 896939..897313 | - | 375 | WP_001094433.1 | toxin | Toxin |
| CPZ97_RS04840 | 897360..897737 | - | 378 | WP_001285603.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| CPZ97_RS04845 | 897787..898431 | - | 645 | WP_000086764.1 | hypothetical protein | - |
| CPZ97_RS04850 | 898450..898671 | - | 222 | WP_000692331.1 | DUF987 domain-containing protein | - |
| CPZ97_RS04855 | 898740..899192 | - | 453 | WP_134802012.1 | RadC family protein | - |
| CPZ97_RS04860 | 899208..899681 | - | 474 | WP_001313575.1 | antirestriction protein | - |
| CPZ97_RS04870 | 899961..900782 | - | 822 | WP_001234573.1 | DUF945 domain-containing protein | - |
| CPZ97_RS04880 | 900883..901056 | - | 174 | WP_000088742.1 | DUF905 family protein | - |
| CPZ97_RS04885 | 901176..901659 | - | 484 | Protein_919 | hypothetical protein | - |
| CPZ97_RS04890 | 902090..902557 | - | 468 | WP_000668907.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | csgD / csgE / csgF / csgG / iroN / iroE / iroD / iroC / iroB / rcsA / ipaH9.8 / ipaH9.8 | 881782..968073 | 86291 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 13918.86 Da Isoelectric Point: 6.8517
>T87685 WP_001094433.1 NZ_CP024466:c897313-896939 [Shigella dysenteriae]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSPLINSIDILRARRVTGLMTRDNYRTVNNITLGKHPEAK
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSPLINSIDILRARRVTGLMTRDNYRTVNNITLGKHPEAK
Download Length: 375 bp
>T87685 NZ_CP024466:c897313-896939 [Shigella dysenteriae]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGTATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCCGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGTGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATAACCCTGGGTAAGCATCCGGAGGCGAAATGA
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGTATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCCGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGTGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATAACCCTGGGTAAGCATCCGGAGGCGAAATGA
Antitoxin
Download Length: 126 a.a. Molecular weight: 13789.72 Da Isoelectric Point: 6.4643
>AT87685 WP_001285603.1 NZ_CP024466:c897737-897360 [Shigella dysenteriae]
VSDTLPGTTLPDDNKDRPWWRLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPAITV
VSDTLPGTTLPDDNKDRPWWRLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPAITV
Download Length: 378 bp
>AT87685 NZ_CP024466:c897737-897360 [Shigella dysenteriae]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGATAACAAAGACCGCCCCTGGTGGAGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCAGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACACTGTATGCGAAAGGGCTGACCTGCGAAGCTGATACCCTTGGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCAGCACCCGCAATCACCGTATAA
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGATAACAAAGACCGCCCCTGGTGGAGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCAGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACACTGTATGCGAAAGGGCTGACCTGCGAAGCTGATACCCTTGGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCAGCACCCGCAATCACCGTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A090NBY3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A090NW75 |