Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 5236733..5237249 Replicon chromosome
Accession NZ_CP024458
Organism Klebsiella pneumoniae strain QS17-0161

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag CR231_RS26105 Protein ID WP_009486548.1
Coordinates 5236965..5237249 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag CR231_RS26100 Protein ID WP_002886901.1
Coordinates 5236733..5236975 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CR231_RS26085 5232761..5233501 + 741 WP_009486551.1 KDGP aldolase family protein -
CR231_RS26090 5233568..5234722 + 1155 WP_020316350.1 lactonase family protein -
CR231_RS26095 5234745..5236655 + 1911 WP_009486549.1 BglG family transcription antiterminator -
CR231_RS26100 5236733..5236975 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
CR231_RS26105 5236965..5237249 + 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CR231_RS26110 5237253..5237717 - 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
CR231_RS26115 5238025..5240163 - 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
CR231_RS26120 5240520..5241263 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
CR231_RS29580 5241266..5241439 - 174 WP_002886906.1 hypothetical protein -
CR231_RS26125 5241524..5241832 + 309 WP_012737232.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T87677 WP_009486548.1 NZ_CP024458:5236965-5237249 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T87677 NZ_CP024458:5236965-5237249 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCAGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT87677 WP_002886901.1 NZ_CP024458:5236733-5236975 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT87677 NZ_CP024458:5236733-5236975 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References