Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3873623..3874280 Replicon chromosome
Accession NZ_CP024458
Organism Klebsiella pneumoniae strain QS17-0161

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag CR231_RS19190 Protein ID WP_002916310.1
Coordinates 3873623..3874033 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag CR231_RS19195 Protein ID WP_002916312.1
Coordinates 3874014..3874280 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CR231_RS19170 3869623..3871356 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
CR231_RS19175 3871362..3872075 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CR231_RS19180 3872098..3872994 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
CR231_RS19185 3873095..3873616 + 522 WP_002916308.1 flavodoxin FldB -
CR231_RS19190 3873623..3874033 - 411 WP_002916310.1 protein YgfX Toxin
CR231_RS19195 3874014..3874280 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
CR231_RS19200 3874526..3875509 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
CR231_RS19205 3875660..3876319 - 660 WP_002916317.1 hemolysin III family protein -
CR231_RS19210 3876483..3876794 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
CR231_RS19215 3876844..3877572 + 729 WP_009485882.1 MurR/RpiR family transcriptional regulator -
CR231_RS19220 3877691..3879124 + 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T87673 WP_002916310.1 NZ_CP024458:c3874033-3873623 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T87673 NZ_CP024458:c3874033-3873623 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT87673 WP_002916312.1 NZ_CP024458:c3874280-3874014 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT87673 NZ_CP024458:c3874280-3874014 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References