Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pmenTA/darT(toxin)
Location 9361..11113 Replicon plasmid pNP7-6
Accession NZ_CP024449
Organism Moraxella osloensis strain NP7

Toxin (Protein)


Gene name pmenT Uniprot ID -
Locus tag NP7_RS13730 Protein ID WP_100271261.1
Coordinates 9361..10011 (+) Length 217 a.a.

Antitoxin (Protein)


Gene name pmenA Uniprot ID A0A0X8K8B7
Locus tag NP7_RS13735 Protein ID WP_036590386.1
Coordinates 10013..11113 (+) Length 367 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP7_RS13700 4519..4851 + 333 Protein_6 transposase domain-containing protein -
NP7_RS13705 4872..5326 + 455 Protein_7 DDE-type integrase/transposase/recombinase -
NP7_RS13710 5374..6069 - 696 Protein_8 IS5 family transposase -
NP7_RS13715 6189..8564 + 2376 WP_100271398.1 FdhF/YdeP family oxidoreductase -
NP7_RS13720 8746..9036 + 291 WP_036590395.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
NP7_RS13725 9033..9302 + 270 WP_100271260.1 type II toxin-antitoxin system YafQ family toxin -
NP7_RS13730 9361..10011 + 651 WP_100271261.1 DUF4433 domain-containing protein Toxin
NP7_RS13735 10013..11113 + 1101 WP_036590386.1 macro domain-containing protein Antitoxin
NP7_RS13740 11382..11987 + 606 WP_100271395.1 recombinase family protein -
NP7_RS13745 12094..12390 + 297 WP_100271382.1 BrnT family toxin -
NP7_RS13750 12362..12667 + 306 WP_100271381.1 BrnA antitoxin family protein -
NP7_RS13755 12993..13875 - 883 Protein_17 prolipoprotein diacylglyceryl transferase -
NP7_RS13760 14059..15531 - 1473 WP_100271380.1 two-component sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..46732 46732


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

ssDNA thymidine ADP-ribosyltransferase, DarT

(17-216)

Antitoxin

Macro domain

(18-142)


Sequences

Toxin        


Download         Length: 217 a.a.        Molecular weight: 25196.57 Da        Isoelectric Point: 6.5776

>T87661 WP_100271261.1 NZ_CP024449:9361-10011 [Moraxella osloensis]
MNYDYSNTLNPSKGLIWRIVHIDNLLWIFANGLHSGNSPIQSPNWQHIGNPELIQKRAKHPVPVGLQGYLNDYVPFYFTP
FSPMLLNIKSGRGVMQRPMQDIVILVSSIDAVESHHLDYVFTNSHAYYQWTNFFTDKQDLDQIDWALLQRRDFSRDPNDL
AKFERYQAEFLIYHHCPISAIIGICCYDDNVKQSIQQLINTSGITLDVYSRPNWYL

Download         Length: 651 bp

>T87661 NZ_CP024449:9361-10011 [Moraxella osloensis]
ATGAATTATGATTATAGTAACACGTTAAATCCAAGCAAAGGATTGATATGGCGGATTGTCCATATTGATAATTTACTGTG
GATATTTGCCAACGGTCTACACAGTGGCAATAGCCCTATTCAATCGCCTAACTGGCAGCATATCGGTAACCCTGAGCTTA
TCCAAAAACGTGCCAAACATCCTGTTCCAGTAGGACTACAAGGCTATCTCAATGATTATGTGCCGTTTTACTTTACCCCA
TTTTCGCCCATGTTACTTAATATAAAATCAGGTCGCGGTGTGATGCAAAGACCCATGCAAGATATCGTGATTTTGGTATC
GTCTATTGATGCGGTAGAAAGCCATCATTTGGACTATGTTTTTACCAATAGCCATGCTTATTACCAATGGACTAATTTTT
TTACTGACAAACAAGACCTAGACCAAATCGATTGGGCATTATTGCAGCGCCGTGATTTTAGCCGTGATCCCAATGACTTG
GCAAAATTTGAGCGTTATCAAGCCGAATTTTTGATTTATCATCATTGCCCCATATCAGCAATTATCGGTATCTGTTGTTA
TGATGACAACGTCAAACAAAGCATTCAACAATTAATCAATACGTCTGGCATTACATTGGATGTATATAGCCGACCCAACT
GGTATCTTTGA

Antitoxin


Download         Length: 367 a.a.        Molecular weight: 41845.12 Da        Isoelectric Point: 7.1732

>AT87661 WP_036590386.1 NZ_CP024449:10013-11113 [Moraxella osloensis]
MITYTQGNLLESNAQALVNTVNTVGVMGKGIALMFKQQFPENFKRYAKACKSGDVKVGEMFVVEVSTSSTQHSQLQAQPH
HKQRWIVNFPTKQHWRAKSKIEWIQAGLQNLRQWLIDNHVESIAIPPLGAGNGGLPWQQVKPLIEQALGDLLNIDIQIFE
PSDSYHSVATAPTTDSLTHARALLYQVIDRYWVLGMECSLLEVHKLMWFLQRAIERHRLVNPLQLSFMPHYYGTYAPNLR
HLLNHLDGSYLLAEKRLPDCKPLDVIWANQTKQAEVEQYLQTSMSDFLPVLIEVDKVIAGFESPFGLELLSTVDWLIYQE
QYPATVEGVRQGMANWSAGEVWAKRKLNLFNVQHIDFALQHLKTIY

Download         Length: 1101 bp

>AT87661 NZ_CP024449:10013-11113 [Moraxella osloensis]
ATGATTACATACACCCAAGGTAATTTACTTGAATCAAATGCTCAAGCTTTGGTTAATACCGTCAATACCGTCGGTGTGAT
GGGCAAAGGTATTGCGTTAATGTTTAAACAACAATTTCCCGAAAATTTCAAACGCTATGCCAAAGCGTGCAAATCAGGGG
ATGTGAAAGTCGGTGAAATGTTTGTGGTTGAAGTTAGTACCTCATCGACTCAACACTCACAGTTACAAGCACAGCCTCAT
CATAAGCAAAGATGGATAGTGAATTTCCCAACCAAACAGCATTGGAGAGCTAAATCAAAAATCGAATGGATACAAGCAGG
ACTGCAGAACTTGCGACAATGGTTAATTGATAATCATGTAGAATCGATAGCTATTCCCCCATTAGGTGCGGGTAATGGCG
GACTGCCCTGGCAACAGGTAAAACCCCTTATCGAACAAGCCTTGGGTGATTTACTAAATATTGATATTCAAATTTTTGAA
CCATCAGATAGCTATCATAGCGTTGCGACTGCACCCACAACTGACAGTCTCACCCATGCCCGAGCCTTGTTGTATCAAGT
GATTGACCGTTATTGGGTGCTTGGTATGGAGTGTAGTTTGCTTGAAGTGCATAAGCTGATGTGGTTTTTGCAACGAGCGA
TTGAGCGTCATCGTTTAGTCAATCCGCTACAGTTATCATTTATGCCACATTATTATGGTACTTATGCCCCAAATCTGCGT
CATTTGCTCAATCACCTAGACGGTAGCTATCTATTGGCTGAAAAACGTCTGCCAGATTGCAAACCTTTGGATGTCATTTG
GGCTAACCAAACCAAACAAGCTGAAGTTGAGCAGTATTTGCAAACGTCAATGTCAGATTTTTTACCTGTTTTGATAGAAG
TTGATAAAGTGATAGCAGGATTTGAGTCGCCGTTTGGTTTGGAGCTGCTATCTACCGTGGATTGGCTGATCTATCAAGAA
CAATATCCCGCTACAGTGGAAGGTGTTAGGCAAGGTATGGCAAATTGGTCAGCAGGGGAAGTTTGGGCAAAACGCAAATT
GAATTTATTTAATGTTCAGCATATTGATTTTGCCCTGCAACATTTGAAAACTATTTATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0X8K8B7

References