Detailed information of TA system TA087660

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pmenTA/darT(toxin)
• Location: 5149..6901
• Replicon: plasmid pNP7-3
• Accession: NZ_CP024446
• Organism: Moraxella osloensis strain NP7

Toxin (Protein)

• Gene name: pmenT
• Uniprot ID: -
• Locus tag: NP7_RS12730
• Protein ID: WP_100271261.1
• Coordinates: 5149..5799 (+)
• Length: 217 a.a.

Antitoxin (Protein)

• Gene name: pmenA
• Uniprot ID: A0A0X8K8B7
• Locus tag: NP7_RS12735
• Protein ID: WP_036590386.1
• Coordinates: 5801..6901 (+)
• Length: 367 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NP7_RS12700	2207..2839	+	633	WP_036590402.1	AAA family ATPase	-
NP7_RS12705	2850..3065	+	216	WP_036590400.1	hypothetical protein	-
NP7_RS12715	3489..3974	+	486	WP_100271259.1	hypothetical protein	-
NP7_RS14185	4145..4288	+	144	WP_158522044.1	hypothetical protein	-
NP7_RS12720	4534..4824	+	291	WP_036590395.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
NP7_RS12725	4821..5090	+	270	WP_100271260.1	type II toxin-antitoxin system YafQ family toxin	-
NP7_RS12730	5149..5799	+	651	WP_100271261.1	DUF4433 domain-containing protein	Toxin
NP7_RS12735	5801..6901	+	1101	WP_036590386.1	macro domain-containing protein	Antitoxin
NP7_RS12740	7273..8205	+	933	WP_100271262.1	hypothetical protein	-
NP7_RS12745	8283..8849	-	567	WP_100271263.1	recombinase family protein	-
NP7_RS12750	9436..10635	+	1200	WP_100271264.1	ATP-binding protein	-
NP7_RS12755	11050..11700	+	651	WP_100271265.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..65541	65541

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• ssDNA thymidine ADP-ribosyltransferase, DarT (17-216)

Antitoxin

• Macro domain (18-142)

Sequences

Toxin

Protein

• Length: 217 a.a.
• Molecular weight: 25196.57 Da
• Isoelectric Point: 6.5776

>T87660 WP_100271261.1 NZ_CP024446:5149-5799 [Moraxella osloensis]
MNYDYSNTLNPSKGLIWRIVHIDNLLWIFANGLHSGNSPIQSPNWQHIGNPELIQKRAKHPVPVGLQGYLNDYVPFYFTP
FSPMLLNIKSGRGVMQRPMQDIVILVSSIDAVESHHLDYVFTNSHAYYQWTNFFTDKQDLDQIDWALLQRRDFSRDPNDL
AKFERYQAEFLIYHHCPISAIIGICCYDDNVKQSIQQLINTSGITLDVYSRPNWYL

Nucleotide

• Length: 651 bp

>T87660 NZ_CP024446:5149-5799 [Moraxella osloensis]
ATGAATTATGATTATAGTAACACGTTAAATCCAAGCAAAGGATTGATATGGCGGATTGTCCATATTGATAATTTACTGTG
GATATTTGCCAACGGTCTACACAGTGGCAATAGCCCTATTCAATCGCCTAACTGGCAGCATATCGGTAACCCTGAGCTTA
TCCAAAAACGTGCCAAACATCCTGTTCCAGTAGGACTACAAGGCTATCTCAATGATTATGTGCCGTTTTACTTTACCCCA
TTTTCGCCCATGTTACTTAATATAAAATCAGGTCGCGGTGTGATGCAAAGACCCATGCAAGATATCGTGATTTTGGTATC
GTCTATTGATGCGGTAGAAAGCCATCATTTGGACTATGTTTTTACCAATAGCCATGCTTATTACCAATGGACTAATTTTT
TTACTGACAAACAAGACCTAGACCAAATCGATTGGGCATTATTGCAGCGCCGTGATTTTAGCCGTGATCCCAATGACTTG
GCAAAATTTGAGCGTTATCAAGCCGAATTTTTGATTTATCATCATTGCCCCATATCAGCAATTATCGGTATCTGTTGTTA
TGATGACAACGTCAAACAAAGCATTCAACAATTAATCAATACGTCTGGCATTACATTGGATGTATATAGCCGACCCAACT
GGTATCTTTGA

Antitoxin

Protein

• Length: 367 a.a.
• Molecular weight: 41845.12 Da
• Isoelectric Point: 7.1732

>AT87660 WP_036590386.1 NZ_CP024446:5801-6901 [Moraxella osloensis]
MITYTQGNLLESNAQALVNTVNTVGVMGKGIALMFKQQFPENFKRYAKACKSGDVKVGEMFVVEVSTSSTQHSQLQAQPH
HKQRWIVNFPTKQHWRAKSKIEWIQAGLQNLRQWLIDNHVESIAIPPLGAGNGGLPWQQVKPLIEQALGDLLNIDIQIFE
PSDSYHSVATAPTTDSLTHARALLYQVIDRYWVLGMECSLLEVHKLMWFLQRAIERHRLVNPLQLSFMPHYYGTYAPNLR
HLLNHLDGSYLLAEKRLPDCKPLDVIWANQTKQAEVEQYLQTSMSDFLPVLIEVDKVIAGFESPFGLELLSTVDWLIYQE
QYPATVEGVRQGMANWSAGEVWAKRKLNLFNVQHIDFALQHLKTIY

Nucleotide

• Length: 1101 bp

>AT87660 NZ_CP024446:5801-6901 [Moraxella osloensis]
ATGATTACATACACCCAAGGTAATTTACTTGAATCAAATGCTCAAGCTTTGGTTAATACCGTCAATACCGTCGGTGTGAT
GGGCAAAGGTATTGCGTTAATGTTTAAACAACAATTTCCCGAAAATTTCAAACGCTATGCCAAAGCGTGCAAATCAGGGG
ATGTGAAAGTCGGTGAAATGTTTGTGGTTGAAGTTAGTACCTCATCGACTCAACACTCACAGTTACAAGCACAGCCTCAC
CATAAGCAAAGATGGATAGTGAATTTCCCAACCAAACAGCATTGGAGAGCTAAATCAAAAATCGAATGGATACAAGCAGG
ACTGCAGAACTTGCGACAATGGTTAATTGATAATCATGTAGAATCGATAGCTATTCCCCCATTAGGTGCGGGTAATGGCG
GACTGCCCTGGCAACAGGTAAAACCCCTTATCGAACAAGCCTTGGGTGATTTACTAAATATTGATATTCAAATTTTTGAA
CCATCAGATAGCTATCATAGCGTTGCGACTGCACCCACAACTGACAGTCTCACCCATGCCCGAGCCTTGTTGTATCAAGT
GATTGACCGTTATTGGGTGCTTGGTATGGAGTGTAGTTTGCTTGAAGTGCATAAGCTGATGTGGTTTTTGCAACGAGCGA
TTGAGCGTCATCGTTTAGTCAATCCGCTACAGTTATCATTTATGCCACATTATTATGGTACTTATGCCCCAAATCTGCGT
CATTTGCTCAATCACCTAGACGGTAGCTATCTATTGGCTGAAAAACGTCTGCCAGATTGCAAACCTTTGGATGTCATTTG
GGCTAACCAAACCAAACAAGCTGAAGTTGAGCAGTATTTGCAAACGTCAATGTCAGATTTTTTACCTGTTTTGATAGAAG
TTGATAAAGTGATAGCAGGATTTGAGTCGCCGTTTGGTTTGGAGCTGCTATCTACCGTGGATTGGCTGATCTATCAAGAA
CAATATCCCGCTACAGTGGAAGGTGTTAGGCAAGGTATGGCAAATTGGTCAGCAGGGGAAGTTTGGGCAAAACGCAAATT
GAATTTATTTAATGTTCAGCATATTGATTTTGCCCTGCAACATTTGAAAACTATTTATTAG

Structures

Antitoxin

• AlphaFold DB: A0A0X8K8B7