Detailed information of TA system TA087631

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-Phd
• Location: 9085..9756
• Replicon: plasmid pTT13-2
• Accession: NZ_CP024424
• Organism: Paracoccus yeei strain TT13

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: PYTT13_RS19365
• Protein ID: WP_099650395.1
• Coordinates: 9085..9501 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: PYTT13_RS19370
• Protein ID: WP_099650396.1
• Coordinates: 9502..9756 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PYTT13_RS19345	4712..5707	+	996	WP_099650392.1	GTP-binding protein	-
PYTT13_RS19350	5783..7066	+	1284	WP_099650393.1	lytic murein transglycosylase	-
PYTT13_RS19355	7086..7481	-	396	WP_028720783.1	acyl-CoA thioesterase	-
PYTT13_RS19360	7550..8938	-	1389	WP_099650394.1	L-cystine transporter	-
PYTT13_RS19365	9085..9501	-	417	WP_099650395.1	type II toxin-antitoxin system VapC family toxin	Toxin
PYTT13_RS19370	9502..9756	-	255	WP_099650396.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
PYTT13_RS19375	9870..11177	-	1308	WP_028720780.1	MFS transporter	-
PYTT13_RS19380	11384..12589	+	1206	WP_099650397.1	ubiquinol oxidase subunit II	-
PYTT13_RS19385	12602..14614	+	2013	WP_099650398.1	cytochrome o ubiquinol oxidase subunit I	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..225271	225271

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-119)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-51)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 14862.96 Da
• Isoelectric Point: 5.6964

>T87631 WP_099650395.1 NZ_CP024424:c9501-9085 [Paracoccus yeei]
MLILDTNVLSALRRPERSPAVAAWLARQDDTALYLSVVTLGEIERGIVRQESQNPPFARDLRDWLTRTVTLFSDRLLPFG
AAEALLWGQLSARLGHAGADLLIAATALAHDAAVVTGNTADFRPTGCRLVDPFAQGAG

Nucleotide

• Length: 417 bp

>T87631 NZ_CP024424:c9501-9085 [Paracoccus yeei]
ATGCTGATCCTGGATACCAATGTCCTGTCGGCGCTGCGCCGCCCCGAACGCAGCCCGGCGGTCGCCGCCTGGCTGGCCCG
GCAGGACGACACCGCGCTCTATCTCTCCGTCGTCACCTTGGGCGAGATCGAGCGCGGCATCGTCCGCCAGGAATCGCAGA
ACCCGCCCTTTGCCCGCGACCTGCGCGACTGGCTGACGCGCACCGTCACGCTGTTTTCCGACCGCCTGCTGCCCTTCGGC
GCGGCCGAGGCGCTGCTCTGGGGCCAGCTTTCCGCCCGGCTGGGCCACGCCGGGGCCGACCTGCTGATCGCGGCGACGGC
GCTTGCGCATGACGCGGCCGTGGTCACCGGCAACACCGCCGATTTCCGGCCGACCGGCTGCCGGCTGGTCGATCCCTTCG
CGCAAGGGGCCGGATAG

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 8966.18 Da
• Isoelectric Point: 10.8056

>AT87631 WP_099650396.1 NZ_CP024424:c9756-9502 [Paracoccus yeei]
MWTLQDAKNRFSAVVDAALAGQPQQVTRRGKPAVVVLAAADYARMLAATQENRGSFAAHLLSFPGPDLSPDSGRARVAPR
DVSF

Nucleotide

• Length: 255 bp

>AT87631 NZ_CP024424:c9756-9502 [Paracoccus yeei]
ATGTGGACGCTTCAGGATGCCAAGAACCGCTTTTCGGCCGTGGTCGATGCGGCGCTTGCCGGCCAGCCGCAGCAGGTGAC
GCGGCGCGGCAAGCCCGCCGTCGTGGTGCTGGCCGCTGCGGATTACGCCCGGATGCTGGCCGCGACGCAGGAAAACCGCG
GCTCCTTCGCCGCCCATCTCCTCAGCTTTCCGGGCCCCGACCTGAGCCCCGATTCCGGGCGCGCCCGGGTGGCCCCGCGC
GACGTCAGCTTCTGA