Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-Phd
Location 2438010..2438693 Replicon chromosome
Accession NZ_CP024422
Organism Paracoccus yeei strain TT13

Toxin (Protein)


Gene name vapC Uniprot ID A0A2D2C1U7
Locus tag PYTT13_RS12220 Protein ID WP_028718935.1
Coordinates 2438265..2438693 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A2D2C1V4
Locus tag PYTT13_RS12215 Protein ID WP_028718936.1
Coordinates 2438010..2438261 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYTT13_RS12185 2433453..2434391 + 939 WP_099648849.1 IS110 family transposase -
PYTT13_RS12190 2434424..2435140 + 717 Protein_2398 ABC transporter ATP-binding protein -
PYTT13_RS12195 2435137..2435778 + 642 WP_099649285.1 ABC transporter ATP-binding protein -
PYTT13_RS12200 2435877..2436926 - 1050 WP_099649286.1 hypothetical protein -
PYTT13_RS23195 2437163..2437363 + 201 Protein_2401 hypothetical protein -
PYTT13_RS12210 2437760..2437956 + 197 Protein_2402 DUF3363 domain-containing protein -
PYTT13_RS12215 2438010..2438261 + 252 WP_028718936.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PYTT13_RS12220 2438265..2438693 + 429 WP_028718935.1 PIN domain-containing protein Toxin
PYTT13_RS12230 2438938..2439174 + 237 Protein_2405 transposase -
PYTT13_RS22830 2439198..2439608 - 411 WP_157767353.1 hypothetical protein -
PYTT13_RS12235 2439667..2441736 - 2070 WP_099649287.1 AAA family ATPase -
PYTT13_RS23200 2441832..2442797 - 966 WP_198406634.1 hypothetical protein -
PYTT13_RS12245 2442967..2443602 - 636 WP_147405541.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-65)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15212.40 Da        Isoelectric Point: 6.9897

>T87630 WP_028718935.1 NZ_CP024422:2438265-2438693 [Paracoccus yeei]
MYLLDTNIVSASAPTRRDADVLAAWMRAHSDRLYLSAITIAEIEAGIARAVRIGASSKAPALRRWLAAVEHFYASRILAF
GIEEARQAGAILDQARAHDPGFEDIAIAATAAAHGLTVLTANERHFAPLGVPYANPLKELPA

Download         Length: 429 bp

>T87630 NZ_CP024422:2438265-2438693 [Paracoccus yeei]
TTGTACCTGCTCGATACCAACATCGTTTCGGCCTCCGCGCCGACGAGGCGAGACGCCGATGTTCTCGCTGCATGGATGCG
CGCCCACAGCGACCGGCTCTATCTCTCGGCCATCACCATCGCCGAGATCGAGGCCGGCATCGCCCGGGCGGTCAGGATCG
GCGCCAGCAGCAAGGCCCCGGCGCTGCGCCGCTGGCTCGCTGCGGTCGAGCATTTCTACGCCAGCCGGATCCTCGCTTTC
GGCATCGAGGAGGCTCGTCAGGCCGGGGCGATCCTCGACCAGGCGCGTGCCCATGATCCGGGCTTCGAGGACATCGCCAT
CGCGGCGACGGCTGCCGCGCATGGCCTGACGGTGCTGACCGCCAACGAGCGGCATTTCGCGCCGCTCGGCGTGCCCTATG
CAAATCCGTTGAAGGAACTGCCCGCATAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9337.72 Da        Isoelectric Point: 7.0152

>AT87630 WP_028718936.1 NZ_CP024422:2438010-2438261 [Paracoccus yeei]
MKELQLRDAKATLSAVIDQAVAGEPTVITRHGRKEAVLLSFEEWQRISRVPDFADLLLAFPGQPEDIPERTRKPARALRD
TSL

Download         Length: 252 bp

>AT87630 NZ_CP024422:2438010-2438261 [Paracoccus yeei]
ATGAAGGAACTCCAGCTCAGGGATGCGAAGGCGACGCTTTCCGCCGTGATCGATCAGGCCGTGGCGGGCGAGCCGACGGT
CATCACCCGGCACGGCCGCAAGGAGGCGGTGCTGCTCTCCTTCGAGGAATGGCAGCGCATCTCGCGAGTTCCGGATTTCG
CCGACCTGCTGCTGGCCTTTCCCGGCCAGCCGGAGGATATCCCCGAACGCACCCGCAAGCCTGCACGCGCGCTGCGGGAT
ACGAGCCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2D2C1U7

Antitoxin

Source ID Structure
AlphaFold DB A0A2D2C1V4

References