Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-Phd
Location 2337260..2337943 Replicon chromosome
Accession NZ_CP024422
Organism Paracoccus yeei strain TT13

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PYTT13_RS11710 Protein ID WP_099649205.1
Coordinates 2337515..2337943 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PYTT13_RS11705 Protein ID WP_099649204.1
Coordinates 2337260..2337511 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYTT13_RS11685 2333029..2333952 + 924 WP_099649200.1 dihydrodipicolinate synthase family protein -
PYTT13_RS11690 2333978..2335495 + 1518 WP_099649201.1 peptide ABC transporter substrate-binding protein -
PYTT13_RS11695 2335542..2336609 + 1068 WP_099649202.1 Ldh family oxidoreductase -
PYTT13_RS11700 2336647..2336952 - 306 WP_099649203.1 hypothetical protein -
PYTT13_RS11705 2337260..2337511 + 252 WP_099649204.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PYTT13_RS11710 2337515..2337943 + 429 WP_099649205.1 PIN domain-containing protein Toxin
PYTT13_RS11715 2338199..2339278 - 1080 WP_099649206.1 ABC transporter substrate-binding protein -
PYTT13_RS11720 2339306..2339778 - 473 Protein_2306 thioesterase family protein -
PYTT13_RS11725 2339775..2340098 - 324 WP_099649207.1 2Fe-2S iron-sulfur cluster binding domain-containing protein -
PYTT13_RS11730 2340111..2341328 - 1218 WP_198406712.1 FAD-dependent oxidoreductase -
PYTT13_RS11735 2341350..2342288 - 939 WP_099649209.1 3-hydroxyacyl-CoA dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-65)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15241.48 Da        Isoelectric Point: 8.5476

>T87629 WP_099649205.1 NZ_CP024422:2337515-2337943 [Paracoccus yeei]
MYLLDTNIVSASAPTRRDADVLAAWMRAHSDRLYLSAITIAEIEAGIARAVRIGASSKAPTLRRWLAAVEHFYASRILAF
GIEEARQAGAILDQARAHDPGFEDIAIAATAAAHGLTVLTANERHFAPLGVPYANPLKKLPA

Download         Length: 429 bp

>T87629 NZ_CP024422:2337515-2337943 [Paracoccus yeei]
TTGTACCTGCTCGATACCAACATTGTTTCGGCCTCCGCGCCGACGAGGCGAGACGCCGATGTTCTCGCTGCATGGATGCG
CGCCCACAGCGACCGGCTCTATCTCTCGGCCATCACCATCGCCGAGATCGAGGCCGGTATTGCCCGGGCGGTCAGGATCG
GCGCCAGCAGCAAGGCCCCGACGCTGCGCCGCTGGCTCGCTGCGGTCGAGCATTTCTACGCCAGCCGGATCCTCGCTTTC
GGCATCGAGGAGGCTCGTCAGGCCGGGGCGATCCTCGACCAGGCGCGTGCCCATGATCCGGGCTTCGAGGACATCGCCAT
CGCGGCGACGGCTGCCGCGCATGGCCTGACGGTGCTGACCGCCAACGAGCGGCATTTCGCGCCGCTCGGCGTGCCCTATG
CAAATCCGTTGAAGAAACTGCCCGCATAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9365.83 Da        Isoelectric Point: 7.0152

>AT87629 WP_099649204.1 NZ_CP024422:2337260-2337511 [Paracoccus yeei]
MKELQLRDAKAMLSAVVDQAVAGEPTVITRHGRKEAVLLSFEEWQRISRVPDFADLLLAFPGQPEDIPERIRKPARALRD
TSL

Download         Length: 252 bp

>AT87629 NZ_CP024422:2337260-2337511 [Paracoccus yeei]
ATGAAGGAACTCCAGCTTAGGGATGCGAAGGCGATGCTCTCCGCCGTGGTCGATCAGGCCGTGGCCGGCGAGCCGACGGT
CATCACCCGGCACGGCCGCAAGGAGGCGGTGCTGCTCTCCTTCGAGGAATGGCAGCGCATCTCGCGCGTTCCGGATTTCG
CCGACCTGCTGCTGGCCTTTCCCGGCCAGCCGGAGGATATCCCCGAACGCATCCGCAAGCCTGCACGCGCGCTGCGGGAT
ACGAGCCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References