Detailed information of TA system TA087628

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2099818..2100468
• Replicon: chromosome
• Accession: NZ_CP024422
• Organism: Paracoccus yeei strain TT13

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: PYTT13_RS10525
• Protein ID: WP_099649056.1
• Coordinates: 2100280..2100468 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: PYTT13_RS10520
• Protein ID: WP_099649055.1
• Coordinates: 2099818..2100213 (-)
• Length: 132 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PYTT13_RS10475	2095302..2095499	+	198	WP_099649046.1	hypothetical protein	-
PYTT13_RS10480	2095660..2096226	+	567	WP_157767335.1	hypothetical protein	-
PYTT13_RS10485	2096223..2097107	+	885	WP_099649048.1	hypothetical protein	-
PYTT13_RS10490	2097200..2097751	+	552	WP_198406619.1	hypothetical protein	-
PYTT13_RS10495	2097751..2098011	+	261	WP_157767336.1	hypothetical protein	-
PYTT13_RS10500	2098004..2098459	+	456	WP_099649051.1	VRR-NUC domain-containing protein	-
PYTT13_RS10505	2098456..2098935	+	480	WP_099649052.1	hypothetical protein	-
PYTT13_RS10515	2099095..2099736	+	642	WP_157767337.1	hypothetical protein	-
PYTT13_RS10520	2099818..2100213	-	396	WP_099649055.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
PYTT13_RS10525	2100280..2100468	-	189	WP_099649056.1	type II toxin-antitoxin system HicA family toxin	Toxin
PYTT13_RS10530	2100569..2101156	+	588	WP_099649057.1	phage tail protein	-
PYTT13_RS10535	2101343..2101918	+	576	WP_198406620.1	terminase small subunit	-
PYTT13_RS10540	2101887..2103731	+	1845	WP_198406621.1	phage terminase large subunit family protein	-
PYTT13_RS10545	2103713..2105356	+	1644	WP_099649060.1	phage portal protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2096223..2124757	28534

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (8-61)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-124)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7068.30 Da
• Isoelectric Point: 10.8095

>T87628 WP_099649056.1 NZ_CP024422:c2100468-2100280 [Paracoccus yeei]
MELETNSRKLLKRLKDEGFEEVSKTGSHLKLRKGDRTVILPHPKKDLPLGTVRGIYRQAGLL

Nucleotide

• Length: 189 bp

>T87628 NZ_CP024422:c2100468-2100280 [Paracoccus yeei]
ATGGAGCTAGAGACCAATTCCCGAAAGCTCCTGAAACGGCTCAAAGACGAAGGGTTCGAGGAAGTCAGCAAGACAGGCTC
ACACCTCAAGCTTCGGAAAGGCGACAGGACCGTCATCCTGCCACATCCGAAGAAAGACCTTCCGCTAGGGACCGTCAGAG
GCATCTACAGACAGGCCGGGCTTCTTTAG

Antitoxin

Protein

• Length: 132 a.a.
• Molecular weight: 14266.14 Da
• Isoelectric Point: 4.2140

>AT87628 WP_099649055.1 NZ_CP024422:c2100213-2099818 [Paracoccus yeei]
MRYFTAIIHKDEGSAYGLTFPDLPGAFAAADDWNGIPAAAAEALDLWFEDMPDVEPASLEEIRKREDVAAELADGAVLMP
VPYIPADTAVQRVNITMERGLLRAIDETAKERGMNRSSFLASAARRELIGA

Nucleotide

• Length: 396 bp

>AT87628 NZ_CP024422:c2100213-2099818 [Paracoccus yeei]
ATGCGATACTTCACCGCGATCATCCACAAGGACGAAGGCAGCGCCTATGGTCTGACCTTCCCCGACCTTCCCGGCGCCTT
CGCTGCCGCCGACGACTGGAACGGCATTCCTGCCGCTGCCGCCGAAGCCCTCGATCTGTGGTTCGAGGACATGCCGGACG
TTGAACCCGCCTCGCTGGAGGAAATCCGCAAGCGCGAGGACGTTGCCGCCGAATTGGCCGACGGGGCTGTGCTTATGCCG
GTCCCCTACATCCCGGCCGATACCGCTGTGCAGCGCGTCAACATCACCATGGAGCGCGGCTTGCTGCGCGCGATTGACGA
GACTGCCAAGGAGCGCGGCATGAACCGGTCGTCGTTTCTGGCTTCAGCTGCGCGCCGCGAATTGATCGGGGCATAA