87622

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 12686..13211 Replicon plasmid pA388
Accession NZ_CP024419
Organism Acinetobacter baumannii strain A388

Toxin (Protein)


Gene name relE Uniprot ID A0A7U3Y3F8
Locus tag A388_RS19620 Protein ID WP_000221350.1
Coordinates 12686..12973 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R9B9T8
Locus tag A388_RS19625 Protein ID WP_000192612.1
Coordinates 12963..13211 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A388_RS19600 8682..8984 + 303 Protein_13 IS1-like element ISAba3 family transposase -
A388_RS19605 9235..9753 + 519 WP_000447193.1 sel1 repeat family protein -
A388_RS19610 9962..10528 - 567 WP_000678311.1 recombinase family protein -
A388_RS19615 11165..12414 - 1250 Protein_16 IS3 family transposase -
A388_RS19620 12686..12973 - 288 WP_000221350.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A388_RS19625 12963..13211 - 249 WP_000192612.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
A388_RS19630 13214..13639 - 426 WP_001083446.1 hypothetical protein -
A388_RS19635 13722..13790 - 69 Protein_20 helix-turn-helix domain-containing protein -
A388_RS19640 13906..14142 - 237 WP_000592589.1 hypothetical protein -
A388_RS19645 14139..14768 - 630 WP_000584713.1 AAA family ATPase -
A388_RS19650 15193..16140 + 948 WP_000845976.1 replication initiation protein RepM -
A388_RS19655 16345..16683 - 339 Protein_24 DUF3387 domain-containing protein -
A388_RS19660 16678..16872 + 195 Protein_25 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aph(3')-Ia / blaOXA-58 - 1..33036 33036


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11054.85 Da        Isoelectric Point: 10.0443

>T87622 WP_000221350.1 NZ_CP024419:c12973-12686 [Acinetobacter baumannii]
MTYKLDFLEEALAEWNKLNPSIKQPLKKKLIKVLENPHIPKNKLSGHPNRYKIKLRSVGYRLVYEVIDDEVVVIVIAVGR
RENNAVYDEANSRHS

Download         Length: 288 bp

>T87622 NZ_CP024419:c12973-12686 [Acinetobacter baumannii]
ATGACCTATAAGTTAGACTTTTTAGAAGAAGCATTAGCAGAATGGAATAAGCTTAATCCAAGTATTAAGCAACCATTGAA
GAAGAAACTGATCAAGGTACTAGAGAATCCTCACATTCCCAAGAATAAGCTCTCAGGACATCCTAACCGCTACAAGATCA
AACTTCGCAGTGTTGGTTATCGTTTGGTTTATGAAGTGATTGATGATGAGGTTGTTGTCATCGTCATTGCCGTAGGCAGA
CGTGAAAACAATGCTGTGTATGATGAAGCCAACTCTCGACATTCATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9246.72 Da        Isoelectric Point: 5.0491

>AT87622 WP_000192612.1 NZ_CP024419:c13211-12963 [Acinetobacter baumannii]
MTQLIHARMTASITELKKSPMDTVLAGKGEPVAILNRNTPAFYCVPADLYETMMEQLEDLELNKIADARANQKRIRVNID
DL

Download         Length: 249 bp

>AT87622 NZ_CP024419:c13211-12963 [Acinetobacter baumannii]
ATGACTCAATTAATCCATGCACGAATGACTGCAAGTATTACTGAACTCAAAAAGAGTCCGATGGATACAGTGTTAGCAGG
TAAAGGTGAACCTGTAGCGATCCTTAATCGTAATACACCAGCGTTTTACTGTGTTCCGGCTGATTTGTATGAAACCATGA
TGGAACAACTGGAAGACCTGGAACTCAACAAAATTGCAGATGCTCGTGCGAATCAAAAACGCATTCGAGTAAATATTGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U3Y3F8

Antitoxin

Source ID Structure
AlphaFold DB R9B9T8

References