Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1700881..1702568 Replicon chromosome
Accession NZ_CP024412
Organism Glaesserella parasuis strain SH0104

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag CRH16_RS08745 Protein ID WP_112063096.1
Coordinates 1701225..1702568 (-) Length 448 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag CRH16_RS08740 Protein ID WP_005713145.1
Coordinates 1700881..1701225 (-) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CRH16_RS08720 1696949..1697899 - 951 WP_005713153.1 ribose-phosphate pyrophosphokinase -
CRH16_RS08725 1697927..1698772 - 846 WP_075605726.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
CRH16_RS08730 1698774..1699406 - 633 WP_112063094.1 lipoprotein insertase outer membrane protein LolB -
CRH16_RS08735 1699527..1700852 - 1326 WP_112063095.1 ATP-dependent RNA helicase SrmB -
CRH16_RS08740 1700881..1701225 - 345 WP_005713145.1 helix-turn-helix domain-containing protein Antitoxin
CRH16_RS08745 1701225..1702568 - 1344 WP_112063096.1 type II toxin-antitoxin system HipA family toxin Toxin
CRH16_RS08750 1702680..1703117 - 438 WP_112063097.1 ribosomal protein S18-alanine N-acetyltransferase -
CRH16_RS08755 1703359..1703604 - 246 WP_112063098.1 M23 family metallopeptidase -
CRH16_RS08760 1703801..1704214 - 414 WP_005713136.1 DNA polymerase III subunit psi -
CRH16_RS08765 1704297..1705238 + 942 WP_010787253.1 16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC -
CRH16_RS08770 1705388..1707563 + 2176 Protein_1634 bifunctional 23S rRNA (guanine(2069)-N(7))-methyltransferase RlmK/23S rRNA (guanine(2445)-N(2))-methyltransferase RlmL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(161-406)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-92)


Sequences

Toxin        


Download         Length: 448 a.a.        Molecular weight: 51053.00 Da        Isoelectric Point: 5.0261

>T87620 WP_112063096.1 NZ_CP024412:c1702568-1701225 [Glaesserella parasuis]
MQIEPLTLQAYIADRWQDIAILTFQADYSLNDFSYLYDLTEILSDNDKAVSFNYPVEFFPHRSVSGWFAFLDDIVPSGAS
RRYWLQKLDIAHLPMAQQNYLLLKQGTIAPVGHLRVKQAVSSFIENEPPRLFEIDDVINRQADFLEYANQRGAMAGGATG
AGGEAPKLLLRQTATQQVWIDNLQQGDAADDFYLVKFPRGKRSVIDCDILRAEFHYYHELASMGFDTIDTTKMRLEEGER
YPSLWLPRFDVYRNEQGKMARYAVESVYAMLEKGAGSLLDHEKVIRQLIAKIENSHLAETGMDFDKQAFVIEWVRRDLLN
IAFGNSDNHGRNTAFLRNQNRIWLAPIYDFAPMKADPEGIPRTTMWDSKGHPALELGGEYRFDLIAEQLDDLCPADKLLD
ALRQTAQQLAGLKARLEARGVPTAILTYPSISLDYLPEKLKRWQLLS

Download         Length: 1344 bp

>T87620 NZ_CP024412:c1702568-1701225 [Glaesserella parasuis]
ATGCAAATCGAACCGCTTACACTTCAGGCCTATATTGCTGATCGTTGGCAGGATATTGCTATTTTGACCTTTCAGGCTGA
TTATAGTCTCAATGATTTTAGCTATCTCTATGATTTAACAGAAATTTTAAGTGATAATGATAAGGCAGTTTCATTTAACT
ACCCTGTGGAATTTTTTCCGCATCGCAGTGTATCGGGCTGGTTTGCATTTTTAGATGATATAGTCCCTTCTGGGGCAAGC
CGGCGTTATTGGTTGCAAAAACTAGATATTGCTCATTTGCCGATGGCTCAACAAAACTATTTGTTATTAAAACAAGGCAC
GATTGCACCTGTCGGGCATTTACGAGTTAAACAAGCGGTCAGTTCTTTTATCGAAAATGAACCCCCTCGCTTATTTGAAA
TAGATGATGTTATCAATCGCCAAGCTGATTTTTTGGAATATGCTAATCAGCGTGGGGCAATGGCTGGCGGTGCAACGGGG
GCTGGTGGCGAAGCGCCGAAATTATTGCTACGCCAAACAGCCACTCAGCAAGTTTGGATTGATAATCTACAACAAGGTGA
CGCTGCCGATGATTTCTATTTAGTCAAGTTTCCGCGTGGGAAACGTAGTGTAATAGATTGCGATATATTGAGAGCTGAAT
TTCACTATTATCACGAATTAGCCTCAATGGGTTTTGATACCATTGATACGACAAAAATGCGATTGGAAGAAGGCGAACGT
TACCCGTCGTTGTGGTTACCTCGCTTTGATGTTTATCGTAATGAACAGGGGAAAATGGCTCGTTATGCCGTTGAATCTGT
TTATGCTATGTTAGAAAAAGGGGCTGGCTCTTTGCTAGATCACGAAAAGGTTATTCGTCAGTTGATTGCCAAAATTGAAA
ATTCTCATCTAGCCGAAACAGGAATGGATTTTGATAAACAGGCTTTTGTGATCGAGTGGGTAAGGCGAGATTTATTGAAT
ATCGCCTTTGGAAATAGCGATAATCACGGACGAAATACGGCTTTCTTACGCAATCAAAATCGTATCTGGCTTGCTCCAAT
TTATGATTTTGCCCCAATGAAAGCAGATCCTGAAGGTATTCCTCGCACGACAATGTGGGATAGTAAAGGTCACCCTGCAT
TAGAATTAGGCGGTGAATATCGTTTTGATCTGATTGCAGAACAGCTTGATGATTTATGTCCAGCCGACAAGTTATTAGAT
GCTTTGCGTCAAACGGCTCAACAGCTCGCTGGGCTTAAAGCACGTTTAGAAGCAAGAGGCGTTCCAACGGCAATTTTGAC
GTACCCCTCAATCAGCTTGGACTATTTACCTGAAAAATTAAAACGTTGGCAATTATTATCATAA

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 13207.48 Da        Isoelectric Point: 10.2782

>AT87620 WP_005713145.1 NZ_CP024412:c1701225-1700881 [Glaesserella parasuis]
MEEIKQARASKSKKTLDIYQRATVRDEIARKLLLNEMSLGQALKYLRLHLLAMKQERYAEIVKVSRKTLSDLENDKGNYS
IDIINQVLRPFELQLGVVPINKTLLRQVLNEQAV

Download         Length: 345 bp

>AT87620 NZ_CP024412:c1701225-1700881 [Glaesserella parasuis]
ATGGAAGAGATCAAACAGGCTAGAGCCTCTAAAAGTAAAAAAACGTTAGATATTTATCAGCGAGCGACTGTGCGAGACGA
AATTGCTCGTAAGCTATTGCTCAATGAGATGAGTTTAGGGCAGGCGTTGAAATATCTACGTTTACATCTACTGGCAATGA
AACAAGAGCGTTATGCAGAGATTGTCAAAGTTTCTCGCAAAACGTTATCTGATTTAGAAAATGATAAGGGCAATTACAGT
ATTGATATTATCAATCAGGTGTTACGCCCCTTTGAATTACAGCTTGGCGTTGTGCCAATAAACAAAACATTACTCAGACA
AGTTTTAAACGAACAAGCGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References