Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-stbD/ParE-DnaT
Location 1398820..1399355 Replicon chromosome
Accession NZ_CP024412
Organism Glaesserella parasuis strain SH0104

Toxin (Protein)


Gene name relE Uniprot ID B8F327
Locus tag CRH16_RS07295 Protein ID WP_012621505.1
Coordinates 1398820..1399104 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A836Z1U9
Locus tag CRH16_RS07300 Protein ID WP_010785924.1
Coordinates 1399101..1399355 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CRH16_RS07275 1394452..1394943 + 492 WP_075592514.1 acetolactate synthase small subunit -
CRH16_RS07280 1395049..1395870 - 822 WP_112063032.1 PHP domain-containing protein -
CRH16_RS07285 1396019..1396978 - 960 WP_112063033.1 S-adenosyl-l-methionine hydroxide adenosyltransferase family protein -
CRH16_RS07290 1397061..1398611 - 1551 WP_112063034.1 exodeoxyribonuclease I -
CRH16_RS07295 1398820..1399104 - 285 WP_012621505.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CRH16_RS07300 1399101..1399355 - 255 WP_010785924.1 plasmid stability protein StbD Antitoxin
CRH16_RS07305 1399472..1400227 - 756 WP_112063035.1 ABC transporter permease -
CRH16_RS07310 1400249..1401145 - 897 WP_075605808.1 ABC transporter ATP-binding protein -
CRH16_RS07315 1401151..1403169 - 2019 WP_112063036.1 DNA polymerase III subunit gamma/tau -
CRH16_RS07320 1403256..1403798 - 543 WP_005712695.1 adenine phosphoribosyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11257.23 Da        Isoelectric Point: 10.4221

>T87618 WP_012621505.1 NZ_CP024412:c1399104-1398820 [Glaesserella parasuis]
MSYTIEFIPSAEKEFRKLSLDLRKQFIEKLKERAENPRVESAKLRGMKDCYKIKLRNAGYRLVYQVIDERIVIKVVAQGK
REHNDVYQKVQLRL

Download         Length: 285 bp

>T87618 NZ_CP024412:c1399104-1398820 [Glaesserella parasuis]
ATGAGCTATACCATTGAATTTATCCCATCAGCAGAAAAAGAGTTCCGTAAACTAAGCTTAGATTTAAGAAAACAATTTAT
CGAAAAACTTAAAGAAAGAGCTGAAAATCCGCGTGTAGAAAGTGCTAAACTTCGTGGAATGAAAGATTGTTATAAAATCA
AATTGCGTAATGCAGGCTATCGTTTGGTGTATCAAGTGATTGATGAACGTATTGTAATCAAAGTGGTTGCACAGGGAAAA
AGGGAGCACAACGACGTTTACCAAAAAGTACAATTACGTTTATAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9333.70 Da        Isoelectric Point: 4.4131

>AT87618 WP_010785924.1 NZ_CP024412:c1399355-1399101 [Glaesserella parasuis]
MPSVILTNTVASITELKTNPMATFNAAGGEAIAILNRNEPAFYCVPPHIYEYLIELADDAELAKLVEERQHEKSYKVDLA
DLLK

Download         Length: 255 bp

>AT87618 NZ_CP024412:c1399355-1399101 [Glaesserella parasuis]
ATGCCAAGTGTTATTTTAACCAATACCGTTGCGAGTATTACAGAACTAAAGACAAATCCAATGGCAACATTCAATGCGGC
AGGCGGTGAGGCAATTGCAATTTTAAACCGAAATGAACCCGCTTTTTATTGTGTACCACCGCATATTTATGAATATCTCA
TTGAGCTTGCTGATGATGCAGAATTAGCAAAATTAGTGGAAGAACGCCAACACGAAAAAAGCTACAAAGTGGATTTAGCG
GATTTATTAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B8F327

Antitoxin

Source ID Structure
AlphaFold DB A0A836Z1U9

References