Detailed information of TA system TA087616

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 796458..796997
• Replicon: chromosome
• Accession: NZ_CP024412
• Organism: Glaesserella parasuis strain SH0104

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B8F4J8
• Locus tag: CRH16_RS04275
• Protein ID: WP_010786322.1
• Coordinates: 796728..796997 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B8F4J9
• Locus tag: CRH16_RS04270
• Protein ID: WP_005714576.1
• Coordinates: 796458..796724 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CRH16_RS04235	793394..793720	+	327	WP_075605745.1	DUF2190 family protein	-
CRH16_RS04240	793713..794018	+	306	WP_010786319.1	bacteriophage tail protein	-
CRH16_RS04245	794022..794555	+	534	WP_075592538.1	phage tail protein	-
CRH16_RS04250	794555..794974	+	420	WP_005714567.1	phage tail protein	-
CRH16_RS04255	794977..795642	+	666	WP_075592537.1	hypothetical protein	-
CRH16_RS04260	795716..796117	+	402	WP_005714571.1	hypothetical protein	-
CRH16_RS04265	796162..796389	+	228	WP_005714573.1	DUF4035 domain-containing protein	-
CRH16_RS04270	796458..796724	+	267	WP_005714576.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
CRH16_RS04275	796728..796997	+	270	WP_010786322.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
CRH16_RS04280	797081..797347	+	267	WP_112062890.1	hypothetical protein	-
CRH16_RS04285	797410..800973	+	3564	WP_112062891.1	tape measure protein	-
CRH16_RS04290	801018..801350	+	333	WP_075605749.1	phage tail protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	767237..843605	76368

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (2-88)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (6-80)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10294.03 Da
• Isoelectric Point: 6.8591

>T87616 WP_010786322.1 NZ_CP024412:796728-796997 [Glaesserella parasuis]
MLQLSPTNAYKRDFKKIASELMASAEYIEVMYCLMHQLPLAEKYKDHPLQGELQGFRDCHIKPDLVLIYAVENNLLRLVR
LGSHSELFG

Nucleotide

• Length: 270 bp

>T87616 NZ_CP024412:796728-796997 [Glaesserella parasuis]
ATGTTACAACTTTCTCCAACAAATGCTTATAAAAGAGATTTTAAAAAGATTGCTTCTGAGTTAATGGCTAGTGCCGAATA
TATAGAAGTGATGTATTGTTTAATGCATCAGTTACCTTTGGCGGAGAAATATAAAGATCACCCATTACAAGGAGAATTAC
AAGGTTTTAGAGATTGCCATATCAAACCTGATCTTGTTTTGATTTATGCGGTTGAAAATAATTTACTTCGCTTGGTACGT
TTAGGATCACATTCCGAATTATTTGGGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9945.38 Da
• Isoelectric Point: 5.0366

>AT87616 WP_005714576.1 NZ_CP024412:796458-796724 [Glaesserella parasuis]
MATINDAFSFRTNTEVKNTAFEVIKSYGMTPSQVFNMLLTEIAYTKTIPLSLNYQPNLETKLAMQEAKSGKNEVYESLEA
FHKAMLAE

Nucleotide

• Length: 267 bp

>AT87616 NZ_CP024412:796458-796724 [Glaesserella parasuis]
ATGGCGACCATTAATGATGCTTTCAGTTTTAGAACAAACACAGAAGTTAAAAATACGGCTTTTGAAGTGATAAAAAGTTA
TGGAATGACTCCATCACAAGTGTTTAATATGCTTCTCACTGAAATTGCATATACTAAAACAATTCCGTTAAGTTTGAATT
ATCAACCAAACCTTGAGACTAAGTTGGCAATGCAGGAAGCTAAATCAGGTAAGAATGAGGTATATGAATCTTTGGAAGCG
TTTCATAAAGCAATGTTAGCGGAGTAA

Structures

Toxin

• AlphaFold DB: B8F4J8

Antitoxin

• AlphaFold DB: B8F4J9