Detailed information of TA system TA087612

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1-Phd
• Location: 766910..767592
• Replicon: plasmid pRspNXC24c
• Accession: NZ_CP024314
• Organism: Rhizobium sp. NXC24

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: NXC24_RS27665
• Protein ID: WP_104826581.1
• Coordinates: 766910..767332 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: NXC24_RS27670
• Protein ID: WP_104826582.1
• Coordinates: 767329..767592 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NXC24_RS27655	762178..764664	+	2487	WP_104826579.1	malto-oligosyltrehalose synthase	-
NXC24_RS27660	764754..766829	+	2076	WP_104826580.1	glycogen debranching protein GlgX	-
NXC24_RS27665	766910..767332	-	423	WP_104826581.1	type II toxin-antitoxin system VapC family toxin	Toxin
NXC24_RS27670	767329..767592	-	264	WP_104826582.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
NXC24_RS27675	767705..768805	-	1101	WP_104826583.1	YihY/virulence factor BrkB family protein	-
NXC24_RS27680	768915..771188	-	2274	WP_104826584.1	cation:proton antiporter	-
NXC24_RS27685	771788..772504	+	717	WP_104826585.1	GntR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	ddhA / katA / icl	1..2379650	2379650

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-123)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (8-58)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 15592.90 Da
• Isoelectric Point: 5.2291

>T87612 WP_104826581.1 NZ_CP024314:c767332-766910 [Rhizobium sp. NXC24]
VRLLLDTNVLSEVTRPRPDAHVLKWLDGLDEDRSFISVVSIAEIRRGVALMDSGRKRDALTEWLAQDLPQRFEHRVLPVN
EPVAVAWGDLMGLAKRNGRGLSSMDGLIAATAIAHDLTLATRNIRDFEGFGIELVDPWVV

Nucleotide

• Length: 423 bp

>T87612 NZ_CP024314:c767332-766910 [Rhizobium sp. NXC24]
GTGAGACTGCTGCTAGACACCAATGTCCTGTCTGAGGTGACAAGACCGCGCCCTGATGCGCATGTTTTGAAATGGCTAGA
TGGTCTCGACGAGGATCGCTCCTTCATCAGTGTCGTATCGATCGCGGAGATCCGGCGCGGGGTAGCACTGATGGATAGCG
GGCGGAAGCGCGACGCGCTGACTGAATGGCTTGCCCAGGACCTGCCGCAACGCTTCGAGCATCGTGTCCTCCCTGTGAAC
GAACCGGTTGCCGTGGCCTGGGGCGATCTGATGGGCCTCGCAAAGCGGAACGGCCGCGGCCTGTCGTCCATGGACGGCCT
GATCGCTGCCACGGCGATTGCCCATGATCTTACCCTTGCAACGCGCAACATAAGAGATTTCGAAGGCTTTGGGATTGAGC
TGGTCGATCCGTGGGTGGTATGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9630.90 Da
• Isoelectric Point: 8.0256

>AT87612 WP_104826582.1 NZ_CP024314:c767592-767329 [Rhizobium sp. NXC24]
MRPTPSEQNWTVASAKAKLSEVIECAQSAPQTITRNGKPSVVVVSAEEWHRKTARKGTLAEFLMGSPLRGADLDLERQRD
DPRDLSL

Nucleotide

• Length: 264 bp

>AT87612 NZ_CP024314:c767592-767329 [Rhizobium sp. NXC24]
ATGCGACCAACACCAAGCGAGCAAAATTGGACGGTCGCCAGCGCAAAGGCGAAGCTTTCCGAGGTCATCGAGTGCGCGCA
ATCCGCGCCGCAGACAATTACGCGAAACGGCAAGCCAAGTGTCGTCGTCGTCTCTGCCGAAGAGTGGCATCGGAAGACTG
CGCGCAAAGGCACGCTTGCAGAGTTTCTGATGGGGTCACCCCTGCGCGGCGCCGATCTGGACCTCGAACGTCAGCGCGAC
GACCCGCGTGATCTTTCGCTGTGA