Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4728421..4729219 Replicon chromosome
Accession NZ_CP024289
Organism Escherichia coli O178:H19 strain 2012C-4431

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1M0ZYM8
Locus tag A5960_RS24660 Protein ID WP_000854904.1
Coordinates 4728421..4728798 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A093DMQ4
Locus tag A5960_RS24665 Protein ID WP_001280952.1
Coordinates 4728845..4729219 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A5960_RS24630 4723767..4724744 + 978 WP_000633221.1 type II secretion system minor pseudopilin GspK -
A5960_RS24635 4724741..4725919 + 1179 WP_001495386.1 type II secretion system protein GspL -
A5960_RS24640 4725921..4726457 + 537 WP_000942786.1 GspM family type II secretion system protein YghD -
A5960_RS24645 4726800..4727642 - 843 Protein_4499 DUF4942 domain-containing protein -
A5960_RS24650 4727727..4727924 - 198 WP_000839249.1 DUF957 domain-containing protein -
A5960_RS24655 4727936..4728424 - 489 WP_000779174.1 hypothetical protein -
A5960_RS24660 4728421..4728798 - 378 WP_000854904.1 TA system toxin CbtA family protein Toxin
A5960_RS24665 4728845..4729219 - 375 WP_001280952.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
A5960_RS24670 4729382..4729603 - 222 WP_000692312.1 DUF987 domain-containing protein -
A5960_RS24675 4729666..4730142 - 477 WP_001186726.1 RadC family protein -
A5960_RS24680 4730158..4730643 - 486 WP_000849592.1 antirestriction protein -
A5960_RS24685 4730698..4731516 - 819 WP_001234620.1 DUF945 domain-containing protein -
A5960_RS24695 4731603..4731836 - 234 WP_001119722.1 DUF905 family protein -
A5960_RS24700 4731915..4732370 - 456 WP_000581504.1 hypothetical protein -
A5960_RS24705 4732446..4733054 - 609 Protein_4510 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-118)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14280.26 Da        Isoelectric Point: 7.2922

>T87589 WP_000854904.1 NZ_CP024289:c4728798-4728421 [Escherichia coli O178:H19]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ

Download         Length: 378 bp

>T87589 NZ_CP024289:c4728798-4728421 [Escherichia coli O178:H19]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGCGATGCAGTGAACTTTCTTGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGAATTC
AGTGCCTGTACCCGTTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13719.50 Da        Isoelectric Point: 6.6249

>AT87589 WP_001280952.1 NZ_CP024289:c4729219-4728845 [Escherichia coli O178:H19]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRNQHTVTLYAKGLTCEADTLGSCGYVYLAVYPAQAPATTS

Download         Length: 375 bp

>AT87589 NZ_CP024289:c4729219-4728845 [Escherichia coli O178:H19]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGTGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAAGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGAAATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGGCACAGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M0ZYM8

Antitoxin

Source ID Structure
AlphaFold DB A0A093DMQ4

References