Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 19438..20082 Replicon plasmid unnamed1
Accession NZ_CP024283
Organism Escherichia albertii strain 2014C-4356

Toxin (Protein)


Gene name hicA Uniprot ID A0A7L6LII1
Locus tag CCF14_RS25055 Protein ID WP_000833471.1
Coordinates 19438..19620 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A7L6LHN8
Locus tag CCF14_RS25060 Protein ID WP_000466317.1
Coordinates 19645..20082 (+) Length 146 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCF14_RS25005 16192..16515 + 324 WP_000432876.1 hypothetical protein -
CCF14_RS25010 16556..16744 + 189 WP_099588182.1 hypothetical protein -
CCF14_RS25015 16842..17066 + 225 WP_000814384.1 hypothetical protein -
CCF14_RS25020 17118..17378 + 261 WP_099588183.1 hypothetical protein -
CCF14_RS25025 17368..17610 + 243 WP_099588184.1 hypothetical protein -
CCF14_RS25030 17621..17908 + 288 WP_099588185.1 hypothetical protein -
CCF14_RS25040 18333..18662 + 330 WP_000449469.1 hypothetical protein -
CCF14_RS25045 18720..18998 + 279 WP_080171973.1 cobalamin biosynthesis protein CbiX -
CCF14_RS25055 19438..19620 + 183 WP_000833471.1 type II toxin-antitoxin system HicA family toxin Toxin
CCF14_RS25060 19645..20082 + 438 WP_000466317.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CCF14_RS25065 20111..20815 - 705 WP_001279867.1 hypothetical protein -
CCF14_RS25070 20812..21573 - 762 WP_001097937.1 conjugal transfer protein TraL -
CCF14_RS25075 21583..21990 - 408 WP_001190619.1 hypothetical protein -
CCF14_RS25080 22336..22671 + 336 WP_000963832.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..40461 40461


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(7-138)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6675.97 Da        Isoelectric Point: 11.0013

>T87547 WP_000833471.1 NZ_CP024283:19438-19620 [Escherichia albertii]
MKSADLLKELIAAGCELKRHKASSHQIWWSPITGKTFPVPHPKKDLPLGTVRSIRKMAGI

Download         Length: 183 bp

>T87547 NZ_CP024283:19438-19620 [Escherichia albertii]
ATGAAATCTGCTGACCTGTTGAAAGAACTGATAGCTGCTGGTTGTGAGTTGAAGCGGCATAAGGCGAGCAGCCACCAGAT
ATGGTGGTCGCCCATAACAGGAAAAACTTTTCCTGTGCCCCATCCGAAAAAAGACTTGCCACTGGGTACTGTCAGATCGA
TCAGAAAAATGGCGGGGATTTAA

Antitoxin


Download         Length: 146 a.a.        Molecular weight: 16227.10 Da        Isoelectric Point: 4.3135

>AT87547 WP_000466317.1 NZ_CP024283:19645-20082 [Escherichia albertii]
MFFSVGVETPKDDHTAYGITVPAFDRFDFGCVSAADTQSEIPVMAREAILAIVEEMVLSGSYSVDDIHDDGCLTYAANQD
YSHCDSWFVIDVDLSEIEGKQQRINIALPDVLIRRIDGFVRESGGVYRDRSHFLAQAARHELSYK

Download         Length: 438 bp

>AT87547 NZ_CP024283:19645-20082 [Escherichia albertii]
ATGTTTTTTTCTGTGGGTGTCGAAACACCGAAAGATGACCATACGGCATATGGTATAACCGTTCCGGCTTTTGATCGTTT
TGATTTTGGCTGTGTCTCTGCTGCCGATACTCAATCAGAAATTCCTGTGATGGCGCGAGAAGCGATATTGGCTATCGTGG
AAGAAATGGTTTTAAGTGGTTCTTATTCTGTTGATGATATTCATGATGACGGCTGTTTAACATATGCCGCAAATCAGGAC
TATAGTCACTGCGATAGCTGGTTTGTAATTGATGTTGATTTGTCTGAAATTGAAGGTAAACAACAACGTATTAATATTGC
GTTGCCTGATGTGTTGATTCGTCGTATTGATGGATTTGTCAGAGAAAGTGGCGGTGTTTACAGAGATCGTAGCCATTTTC
TTGCTCAGGCCGCGCGGCATGAACTTTCATATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L6LII1

Antitoxin

Source ID Structure
AlphaFold DB A0A7L6LHN8

References