Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2370586..2371237 Replicon chromosome
Accession NZ_CP024282
Organism Escherichia albertii strain 2014C-4356

Toxin (Protein)


Gene name cptA Uniprot ID B1EG01
Locus tag CCF14_RS12110 Protein ID WP_000244763.1
Coordinates 2370833..2371237 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag CCF14_RS12105 Protein ID WP_000354046.1
Coordinates 2370586..2370852 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCF14_RS12080 2366417..2367850 - 1434 WP_059258660.1 6-phospho-beta-glucosidase BglA -
CCF14_RS12085 2367895..2368206 + 312 WP_059258658.1 N(4)-acetylcytidine aminohydrolase -
CCF14_RS12090 2368374..2369033 + 660 WP_000250281.1 hemolysin III family protein -
CCF14_RS12095 2369354..2370334 - 981 WP_059216761.1 tRNA-modifying protein YgfZ -
CCF14_RS12100 2370366..2370596 + 231 WP_000181267.1 hypothetical protein -
CCF14_RS12105 2370586..2370852 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
CCF14_RS12110 2370833..2371237 + 405 WP_000244763.1 protein YgfX Toxin
CCF14_RS12115 2371271..2371792 - 522 WP_054410387.1 flavodoxin FldB -
CCF14_RS12120 2371904..2372800 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
CCF14_RS12125 2372825..2373535 + 711 WP_059214529.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CCF14_RS12130 2373541..2375274 + 1734 WP_059214528.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15888.81 Da        Isoelectric Point: 11.1732

>T87531 WP_000244763.1 NZ_CP024282:2370833-2371237 [Escherichia albertii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAAILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVRAPWMIKTGMMLRLLSDSGKRQHLWLAADSMDEAEWRDLRRILLQQEIQ

Download         Length: 405 bp

>T87531 NZ_CP024282:2370833-2371237 [Escherichia albertii]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCGCAGTGGCTCTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGCTATTTTACTCATGCCCTGGCCGCTAAGTTATACCCCGTTATGGATGGTGTTGCTTTCGCTGGTGGTGTTTGATTGCG
TCCGCAGTCAGCGGCGCATTAATGCTCGTCAGGGGGAGATTCGCCTGTTGATGGATGGGCGTTTACGCTGGCAGGGGCAG
GAGTGGAGCATCGTCAGAGCGCCGTGGATGATTAAAACTGGCATGATGTTGCGTTTACTCTCTGATAGCGGCAAACGTCA
GCACCTGTGGCTGGCAGCCGACAGTATGGATGAAGCTGAATGGCGGGATTTGCGGCGAATTTTGTTACAACAAGAGATAC
AGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT87531 WP_000354046.1 NZ_CP024282:2370586-2370852 [Escherichia albertii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT87531 NZ_CP024282:2370586-2370852 [Escherichia albertii]
ATGGACATTAACAATAAAGCCCGCATTCACTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGATAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGACTGCTGGAGTGTGACGATCCCGATT
TATTCAACTGGTTGATGAATCACGGTAAACCGGCCGACGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6P9B3

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References