Detailed information of TA system TA087503

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 2586389..2587233
• Replicon: chromosome
• Accession: NZ_CP024278
• Organism: Escherichia coli strain ATCC 43896

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: B1LJY4
• Locus tag: CS031_RS13790
• Protein ID: WP_000854686.1
• Coordinates: 2586389..2586772 (-)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: A0A8E0J1S3
• Locus tag: CS031_RS13795
• Protein ID: WP_001285602.1
• Coordinates: 2586853..2587233 (-)
• Length: 127 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CS031_RS13750	2581391..2581882	-	492	WP_001297187.1	DUF1097 domain-containing protein	-
CS031_RS13755	2581984..2582538	-	555	WP_001001902.1	molecular chaperone YcdY	-
CS031_RS13760	2582562..2583299	-	738	WP_000283664.1	zinc-binding phosphatase	-
CS031_RS13765	2583354..2584292	-	939	WP_000351317.1	glyoxylate/hydroxypyruvate reductase GhrA	-
CS031_RS13775	2584763..2585605	-	843	WP_001696893.1	DUF4942 domain-containing protein	-
CS031_RS13780	2585690..2585887	-	198	WP_000839253.1	DUF957 domain-containing protein	-
CS031_RS13785	2585904..2586392	-	489	WP_001696892.1	hypothetical protein	-
CS031_RS13790	2586389..2586772	-	384	WP_000854686.1	TA system toxin CbtA family protein	Toxin
CS031_RS13795	2586853..2587233	-	381	WP_001285602.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
CS031_RS13800	2587244..2587927	-	684	WP_001696891.1	hypothetical protein	-
CS031_RS13805	2587946..2588167	-	222	WP_001696890.1	DUF987 domain-containing protein	-
CS031_RS13810	2588230..2588706	-	477	WP_001186726.1	RadC family protein	-
CS031_RS13815	2588722..2589207	-	486	WP_001697217.1	antirestriction protein	-
CS031_RS13820	2589299..2590117	-	819	WP_001697216.1	DUF945 domain-containing protein	-
CS031_RS13830	2590217..2590450	-	234	WP_001119719.1	DUF905 family protein	-
CS031_RS13835	2590529..2590983	-	455	Protein_2548	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-113)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 14272.28 Da
• Isoelectric Point: 6.8614

>T87503 WP_000854686.1 NZ_CP024278:c2586772-2586389 [Escherichia coli]
MKTLPDTHVRAASRCPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGAPSSQLINSIDILRARRATGLMTRDNYRMVNNITLGKHPEEAKQ

Nucleotide

• Length: 384 bp

>T87503 NZ_CP024278:c2586772-2586389 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTTACGTTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGTGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGTCTCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCG
GGACAATTACAGAATGGTAAATAACATTACCCTGGGCAAGCATCCGGAGGAGGCGAAACAATGA

Antitoxin

Protein

• Length: 127 a.a.
• Molecular weight: 13938.69 Da
• Isoelectric Point: 5.0823

>AT87503 WP_001285602.1 NZ_CP024278:c2587233-2586853 [Escherichia coli]
VSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Nucleotide

• Length: 381 bp

>AT87503 NZ_CP024278:c2587233-2586853 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAACAAAGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGGCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTCCGGAATAG