Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 586332..586950 Replicon chromosome
Accession NZ_CP024275
Organism Escherichia coli O6:H16 strain M9682-C1

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag COG40_RS02995 Protein ID WP_001291435.1
Coordinates 586332..586550 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag COG40_RS03000 Protein ID WP_000344789.1
Coordinates 586576..586950 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
COG40_RS02960 581621..582193 + 573 WP_000779831.1 YbaY family lipoprotein -
COG40_RS02965 582224..582535 - 312 WP_000409911.1 MGMT family protein -
COG40_RS02975 582914..583267 + 354 WP_000878143.1 DUF1428 domain-containing protein -
COG40_RS02980 583309..584859 - 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
COG40_RS02985 585023..585493 - 471 WP_000136192.1 YlaC family protein -
COG40_RS02990 585609..586160 - 552 WP_000102564.1 maltose O-acetyltransferase -
COG40_RS02995 586332..586550 - 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
COG40_RS03000 586576..586950 - 375 WP_000344789.1 Hha toxicity modulator TomB Antitoxin
COG40_RS03005 587496..590645 - 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
COG40_RS03010 590668..591861 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T87464 WP_001291435.1 NZ_CP024275:c586550-586332 [Escherichia coli O6:H16]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T87464 NZ_CP024275:c586550-586332 [Escherichia coli O6:H16]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14569.44 Da        Isoelectric Point: 4.7395

>AT87464 WP_000344789.1 NZ_CP024275:c586950-586576 [Escherichia coli O6:H16]
MDEYSPKRHDIAQLKFLCEILYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT87464 NZ_CP024275:c586950-586576 [Escherichia coli O6:H16]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAATCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure

References