Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 17857..18404 Replicon plasmid unnamed1
Accession NZ_CP024270
Organism Escherichia coli strain F8111-1SC3

Toxin (Protein)


Gene name parE Uniprot ID E9LLH3
Locus tag CCV27_RS24955 Protein ID WP_000969996.1
Coordinates 17857..18138 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A0S0ZPX5
Locus tag CCV27_RS24960 Protein ID WP_032291093.1
Coordinates 18135..18404 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCV27_RS24940 13212..13769 - 558 WP_001235713.1 recombinase family protein -
CCV27_RS24945 13933..16938 + 3006 WP_001143760.1 Tn3-like element Tn3 family transposase -
CCV27_RS24950 16963..17817 - 855 WP_080060530.1 3'-5' exonuclease -
CCV27_RS24955 17857..18138 - 282 WP_000969996.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CCV27_RS24960 18135..18404 - 270 WP_032291093.1 hypothetical protein Antitoxin
CCV27_RS27300 18459..18617 - 159 WP_038349023.1 hypothetical protein -
CCV27_RS24975 19315..20346 - 1032 WP_052991836.1 replication initiation protein -
CCV27_RS24990 21320..21583 + 264 WP_001387472.1 ash family protein -
CCV27_RS24995 21501..21788 + 288 WP_000074855.1 conjugal transfer protein TraA -
CCV27_RS25005 22230..22763 + 534 WP_001372168.1 transcription termination factor NusG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaTEM-1B - 1..35769 35769


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10893.57 Da        Isoelectric Point: 8.4615

>T87436 WP_000969996.1 NZ_CP024270:c18138-17857 [Escherichia coli]
MMEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKV
YILRVLHTAQKWP

Download         Length: 282 bp

>T87436 NZ_CP024270:c18138-17857 [Escherichia coli]
ATGATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGAT
GGCCGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTC
GTGTGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTG
TATATCCTGCGCGTGTTGCATACTGCACAGAAGTGGCCATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10069.43 Da        Isoelectric Point: 8.0565

>AT87436 WP_032291093.1 NZ_CP024270:c18404-18135 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLGCGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp

>AT87436 NZ_CP024270:c18404-18135 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
CGGCAGGACGTCAGCAACTCGGGTGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCCGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAGGTTGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E9LLH3

Antitoxin

Source ID Structure
AlphaFold DB A0A0S0ZPX5

References