Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2668283..2669115 Replicon chromosome
Accession NZ_CP024269
Organism Escherichia coli strain F8111-1SC3

Toxin (Protein)


Gene name yeeV Uniprot ID E3PN67
Locus tag CCV27_RS13630 Protein ID WP_000854775.1
Coordinates 2668741..2669115 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A426P7N5
Locus tag CCV27_RS13625 Protein ID WP_001285645.1
Coordinates 2668283..2668651 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCV27_RS13590 2664107..2664787 + 681 WP_001282911.1 WYL domain-containing protein -
CCV27_RS13595 2664938..2665615 + 678 WP_001097567.1 hypothetical protein -
CCV27_RS13600 2665621..2665854 + 234 WP_001278284.1 DUF905 family protein -
CCV27_RS13605 2665944..2666761 + 818 Protein_2521 DUF932 domain-containing protein -
CCV27_RS13610 2666853..2667338 + 486 WP_000213721.1 antirestriction protein -
CCV27_RS13615 2667354..2667830 + 477 WP_001186201.1 RadC family protein -
CCV27_RS13620 2667899..2668120 + 222 WP_000692303.1 DUF987 domain-containing protein -
CCV27_RS13625 2668283..2668651 + 369 WP_001285645.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CCV27_RS13630 2668741..2669115 + 375 WP_000854775.1 TA system toxin CbtA family protein Toxin
CCV27_RS13635 2669112..2669603 + 492 WP_000976825.1 hypothetical protein -
CCV27_RS13640 2669615..2669812 + 198 WP_000772035.1 DUF957 domain-containing protein -
CCV27_RS13645 2669897..2670739 + 843 WP_001274548.1 DUF4942 domain-containing protein -
CCV27_RS13655 2670977..2671141 + 165 Protein_2530 virulence RhuM family protein -
CCV27_RS13660 2671538..2672722 + 1185 WP_001719114.1 sugar efflux transporter -
CCV27_RS13665 2672833..2673756 + 924 WP_000535959.1 carboxylate/amino acid/amine transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2628897..2682346 53449


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13965.02 Da        Isoelectric Point: 8.2830

>T87432 WP_000854775.1 NZ_CP024269:2668741-2669115 [Escherichia coli]
MKTLPDTLVREASRCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAK

Download         Length: 375 bp

>T87432 NZ_CP024269:2668741-2669115 [Escherichia coli]
ATGAAAACATTACCCGATACACTCGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTGCTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13678.37 Da        Isoelectric Point: 5.4492

>AT87432 WP_001285645.1 NZ_CP024269:2668283-2668651 [Escherichia coli]
VSDTLSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRADIRGRFSDADAYHLDQAFPLLMKQLELMLTNG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT87432 NZ_CP024269:2668283-2668651 [Escherichia coli]
GTGTCAGACACACTCTCCGGGACAACGCATCCCGATGACAATCACGACCGTCCCTGGTGGGGACTACCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGATATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAACGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E3PN67

Antitoxin

Source ID Structure
AlphaFold DB A0A426P7N5

References