Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4640170..4640788 Replicon chromosome
Accession NZ_CP024266
Organism Escherichia coli O6:H16 strain F6699

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag COG39_RS22850 Protein ID WP_001291435.1
Coordinates 4640570..4640788 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag COG39_RS22845 Protein ID WP_000344789.1
Coordinates 4640170..4640544 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
COG39_RS22835 (4635259) 4635259..4636452 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
COG39_RS22840 (4636475) 4636475..4639624 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
COG39_RS22845 (4640170) 4640170..4640544 + 375 WP_000344789.1 Hha toxicity modulator TomB Antitoxin
COG39_RS22850 (4640570) 4640570..4640788 + 219 WP_001291435.1 HHA domain-containing protein Toxin
COG39_RS22855 (4640960) 4640960..4641511 + 552 WP_000102564.1 maltose O-acetyltransferase -
COG39_RS22860 (4641627) 4641627..4642097 + 471 WP_000136192.1 YlaC family protein -
COG39_RS22865 (4642261) 4642261..4643811 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
COG39_RS22870 (4643853) 4643853..4644206 - 354 WP_000878143.1 DUF1428 domain-containing protein -
COG39_RS22880 (4644585) 4644585..4644896 + 312 WP_000409911.1 MGMT family protein -
COG39_RS22885 (4644927) 4644927..4645499 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T87411 WP_001291435.1 NZ_CP024266:4640570-4640788 [Escherichia coli O6:H16]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T87411 NZ_CP024266:4640570-4640788 [Escherichia coli O6:H16]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14569.44 Da        Isoelectric Point: 4.7395

>AT87411 WP_000344789.1 NZ_CP024266:4640170-4640544 [Escherichia coli O6:H16]
MDEYSPKRHDIAQLKFLCEILYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT87411 NZ_CP024266:4640170-4640544 [Escherichia coli O6:H16]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAATCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure

References