Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 40452..41026 Replicon plasmid unnamed2
Accession NZ_CP024265
Organism Escherichia coli O169:H41 strain F6326-C1

Toxin (Protein)


Gene name relE Uniprot ID A0A0S3PMZ8
Locus tag COG38_RS25925 Protein ID WP_001595119.1
Coordinates 40452..40778 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0S3PN98
Locus tag COG38_RS25930 Protein ID WP_001595120.1
Coordinates 40775..41026 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
COG38_RS25890 35986..37521 + 1536 WP_000447015.1 IS21 family transposase -
COG38_RS25895 37538..38293 + 756 WP_001282653.1 IS21-like element ISSso4 family helper ATPase IstB -
COG38_RS25915 38875..40052 - 1178 Protein_41 IS91 family transposase -
COG38_RS25920 40052..40348 - 297 WP_000766063.1 hypothetical protein -
COG38_RS25925 40452..40778 - 327 WP_001595119.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
COG38_RS25930 40775..41026 - 252 WP_001595120.1 hypothetical protein Antitoxin
COG38_RS25935 41580..42446 + 867 WP_001595122.1 AAA family ATPase -
COG38_RS25940 42446..43477 + 1032 WP_001595123.1 ParB/RepB/Spo0J family partition protein -
COG38_RS25945 43501..43914 + 414 WP_032159708.1 hypothetical protein -
COG38_RS27240 43911..44234 + 324 WP_000143877.1 hypothetical protein -
COG38_RS25955 44273..45547 - 1275 WP_001595125.1 Y-family DNA polymerase -
COG38_RS25960 45547..45969 - 423 WP_001595126.1 translesion error-prone DNA polymerase V autoproteolytic subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - faeE / faeD / cofA / cssA / estIa 1..150389 150389


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12187.44 Da        Isoelectric Point: 10.4373

>T87390 WP_001595119.1 NZ_CP024265:c40778-40452 [Escherichia coli O169:H41]
MTYTVKFRDDALKEWLKLDKAIQQQFAKKLKKCSENPHIPSAKLRGIKDCYKIKLRASGFRLVYQVIDDQLIIAVVAIGK
RERSDVYNLASRVGSLAAAACHGLKLPL

Download         Length: 327 bp

>T87390 NZ_CP024265:c40778-40452 [Escherichia coli O169:H41]
ATGACTTACACAGTCAAATTCAGGGATGATGCACTGAAAGAATGGCTGAAACTGGATAAGGCCATTCAACAGCAATTTGC
TAAAAAGCTAAAGAAGTGCAGTGAAAATCCTCATATTCCCTCTGCTAAGCTGCGCGGGATAAAAGACTGCTACAAAATAA
AATTACGTGCGTCAGGTTTTCGCCTAGTCTATCAGGTGATAGATGATCAATTAATTATCGCTGTTGTTGCTATTGGGAAA
CGTGAACGTAGTGATGTTTATAATCTTGCCAGCCGAGTAGGCAGCCTGGCGGCTGCGGCTTGTCATGGACTGAAATTACC
GTTATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9144.43 Da        Isoelectric Point: 4.2975

>AT87390 WP_001595120.1 NZ_CP024265:c41026-40775 [Escherichia coli O169:H41]
MPNIILTDTSASVSELKKNPMATVSAGDGYPVAILNRNQPAFYCVPAELYGKMLDAMDDQELVKLVAERSNQKLHDVDLD
SYL

Download         Length: 252 bp

>AT87390 NZ_CP024265:c41026-40775 [Escherichia coli O169:H41]
ATGCCTAACATCATTCTTACCGACACAAGCGCCAGTGTAAGCGAACTTAAGAAAAACCCGATGGCTACAGTCAGCGCTGG
TGATGGCTACCCAGTTGCTATTCTGAACCGCAACCAGCCAGCCTTTTACTGCGTACCCGCAGAGTTGTACGGAAAGATGC
TCGATGCCATGGACGATCAGGAACTGGTTAAGCTAGTCGCCGAACGCAGCAACCAGAAGCTGCACGATGTGGATCTGGAT
AGCTACTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0S3PMZ8

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3PN98

References