Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2551601..2552255 Replicon chromosome
Accession NZ_CP024263
Organism Escherichia coli O169:H41 strain F6326-C1

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag COG38_RS13115 Protein ID WP_000244781.1
Coordinates 2551601..2552008 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag COG38_RS13120 Protein ID WP_000354046.1
Coordinates 2551989..2552255 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
COG38_RS13095 2547558..2549291 - 1734 WP_000813202.1 single-stranded-DNA-specific exonuclease RecJ -
COG38_RS13100 2549297..2550007 - 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
COG38_RS13105 2550032..2550928 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
COG38_RS13110 2551040..2551561 + 522 WP_001613762.1 flavodoxin FldB -
COG38_RS13115 2551601..2552008 - 408 WP_000244781.1 protein YgfX Toxin
COG38_RS13120 2551989..2552255 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
COG38_RS13125 2552498..2553478 + 981 WP_001613766.1 tRNA-modifying protein YgfZ -
COG38_RS13130 2553555..2554214 - 660 WP_000250274.1 hemolysin III family protein -
COG38_RS13135 2554378..2554689 - 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
COG38_RS13140 2554734..2556167 + 1434 WP_032200731.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T87381 WP_000244781.1 NZ_CP024263:c2552008-2551601 [Escherichia coli O169:H41]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T87381 NZ_CP024263:c2552008-2551601 [Escherichia coli O169:H41]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCGCAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT87381 WP_000354046.1 NZ_CP024263:c2552255-2551989 [Escherichia coli O169:H41]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT87381 NZ_CP024263:c2552255-2551989 [Escherichia coli O169:H41]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCAGACC
TGTTCAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References