Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3062815..3063650 Replicon chromosome
Accession NZ_CP024260
Organism Escherichia coli strain F5656C1

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag A4V61_RS16145 Protein ID WP_000854743.1
Coordinates 3062815..3063192 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag A4V61_RS16150 Protein ID WP_001285298.1
Coordinates 3063282..3063650 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4V61_RS16110 3058172..3059095 - 924 WP_000535961.1 carboxylate/amino acid/amine transporter -
A4V61_RS16115 3059206..3060390 - 1185 WP_001172882.1 sugar efflux transporter -
A4V61_RS16130 3061186..3062024 - 839 Protein_2904 DUF4942 domain-containing protein -
A4V61_RS16135 3062121..3062318 - 198 WP_000839275.1 DUF957 domain-containing protein -
A4V61_RS16140 3062330..3062818 - 489 WP_000761693.1 hypothetical protein -
A4V61_RS16145 3062815..3063192 - 378 WP_000854743.1 TA system toxin CbtA family protein Toxin
A4V61_RS16150 3063282..3063650 - 369 WP_001285298.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
A4V61_RS16155 3063700..3064344 - 645 WP_000086754.1 hypothetical protein -
A4V61_RS16160 3064363..3064584 - 222 WP_000692295.1 DUF987 domain-containing protein -
A4V61_RS16165 3064653..3065129 - 477 WP_032328266.1 RadC family protein -
A4V61_RS16170 3065144..3065629 - 486 WP_000206660.1 antirestriction protein -
A4V61_RS16175 3065721..3066542 - 822 WP_001706654.1 DUF945 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3061420..3099560 38140


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14172.08 Da        Isoelectric Point: 6.8519

>T87357 WP_000854743.1 NZ_CP024260:c3063192-3062815 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDSVNFLVEKYALVRTDQPGF
GACTYSQLINSIDILRARRATGLMTRDNYRTVNDITQGKHPEAKQ

Download         Length: 378 bp

>T87357 NZ_CP024260:c3063192-3062815 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATTCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
GGTGCCTGTACCTATTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCCCGCCGGGCGACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATGACATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13710.44 Da        Isoelectric Point: 5.8799

>AT87357 WP_001285298.1 NZ_CP024260:c3063650-3063282 [Escherichia coli]
MSDSRHETNYPDDHNDRPWWGLPCTVIPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRHQHTVTLYAKGLTCEADTLGSCGCVYLAVYPTPETKN

Download         Length: 369 bp

>AT87357 NZ_CP024260:c3063650-3063282 [Escherichia coli]
ATGTCAGACTCGCGCCATGAGACAAATTATCCCGACGACCATAACGACCGCCCCTGGTGGGGACTGCCCTGCACCGTGAT
ACCCTGTTTTGGCGCCCGTCTGGTGCAGGAAGGCAACCAGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTCAGCCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTGCGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References