Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2517929..2518763 Replicon chromosome
Accession NZ_CP024260
Organism Escherichia coli strain F5656C1

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag A4V61_RS13385 Protein ID WP_032328463.1
Coordinates 2518386..2518763 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag A4V61_RS13380 Protein ID WP_024183700.1
Coordinates 2517929..2518297 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4V61_RS13340 2513655..2514539 + 885 WP_000010388.1 50S ribosome-binding GTPase -
A4V61_RS26315 2514658..2514918 + 261 WP_172902803.1 hypothetical protein -
A4V61_RS26320 2514958..2515335 + 378 WP_172902802.1 hypothetical protein -
A4V61_RS13350 2515341..2515574 + 234 WP_001278281.1 DUF905 family protein -
A4V61_RS13360 2515673..2516491 + 819 WP_001234693.1 DUF945 domain-containing protein -
A4V61_RS13365 2516583..2517068 + 486 WP_000206660.1 antirestriction protein -
A4V61_RS13370 2517083..2517559 + 477 WP_032328266.1 RadC family protein -
A4V61_RS13375 2517628..2517849 + 222 WP_000692295.1 DUF987 domain-containing protein -
A4V61_RS13380 2517929..2518297 + 369 WP_024183700.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
A4V61_RS13385 2518386..2518763 + 378 WP_032328463.1 TA system toxin CbtA family protein Toxin
A4V61_RS13390 2518760..2519248 + 489 WP_032328344.1 hypothetical protein -
A4V61_RS13395 2519260..2519457 + 198 WP_000839291.1 DUF957 domain-containing protein -
A4V61_RS13400 2519542..2520408 + 867 WP_001280426.1 DUF4942 domain-containing protein -
A4V61_RS13405 2520480..2520743 + 264 WP_001143297.1 type II toxin-antitoxin system ParD family antitoxin -
A4V61_RS13410 2520740..2521066 + 327 WP_000779483.1 type II toxin-antitoxin system RelE/ParE family toxin -
A4V61_RS13415 2521512..2522756 + 1245 WP_001219071.1 integrase arm-type DNA-binding domain-containing protein -
A4V61_RS13425 2522819..2523516 + 698 Protein_2432 IS1 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - vipB/tssC / vipA/tssB 2473587..2596659 123072
- flank IS/Tn - - 2523139..2523516 377


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14335.35 Da        Isoelectric Point: 9.2442

>T87355 WP_032328463.1 NZ_CP024260:2518386-2518763 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPRF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHSEAKR

Download         Length: 378 bp

>T87355 NZ_CP024260:2518386-2518763 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTGTC
CCGCCTGCTGGACCAGCATTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGTATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTGCGTACCGACCAGCCCCGGTTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCGGGGTAAGCATTCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13617.41 Da        Isoelectric Point: 7.7474

>AT87355 WP_024183700.1 NZ_CP024260:2517929-2518297 [Escherichia coli]
VSDTFSGTTHPDDNRGRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCKADTLGSCGYVYLAVYPTSETKK

Download         Length: 369 bp

>AT87355 NZ_CP024260:2517929-2518297 [Escherichia coli]
GTGTCAGACACATTCTCCGGGACAACTCATCCCGACGACAATCGCGGCCGCCCCTGGTGGGGACTGCCCTGTACCGTGAC
ACCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAATTAATGCTCACCAGCGGT
GAATTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCAAAGCCGACACCCTCGGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCAACATCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References