87310

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4858811..4859465 Replicon chromosome
Accession NZ_CP024256
Organism Escherichia coli strain ATCC 43886

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag CS032_RS26895 Protein ID WP_000244781.1
Coordinates 4858811..4859218 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag CS032_RS26900 Protein ID WP_000354046.1
Coordinates 4859199..4859465 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CS032_RS26875 4854768..4856501 - 1734 WP_000813233.1 single-stranded-DNA-specific exonuclease RecJ -
CS032_RS26880 4856507..4857217 - 711 WP_000715222.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CS032_RS26885 4857242..4858138 - 897 WP_001735667.1 site-specific tyrosine recombinase XerD -
CS032_RS26890 4858250..4858771 + 522 WP_001055874.1 flavodoxin FldB -
CS032_RS26895 4858811..4859218 - 408 WP_000244781.1 protein YgfX Toxin
CS032_RS26900 4859199..4859465 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
CS032_RS26905 4859708..4860688 + 981 WP_000886087.1 tRNA-modifying protein YgfZ -
CS032_RS26910 4860765..4861424 - 660 WP_000250274.1 hemolysin III family protein -
CS032_RS26915 4861588..4861899 - 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
CS032_RS26920 4861944..4863377 + 1434 WP_001394742.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T87310 WP_000244781.1 NZ_CP024256:c4859218-4858811 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T87310 NZ_CP024256:c4859218-4858811 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATCCACGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGACGCATTAATGCTCGCCAGGGAGAAATTCGCCTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT87310 WP_000354046.1 NZ_CP024256:c4859465-4859199 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT87310 NZ_CP024256:c4859465-4859199 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCCGATC
TGTTCAACTGGCTGATGAATCATGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QD57

References