Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3066696..3067350 Replicon chromosome
Accession NZ_CP024243
Organism Escherichia coli O128:H27 strain 90-9281

Toxin (Protein)


Gene name cptA Uniprot ID F4NJ21
Locus tag COG34_RS15940 Protein ID WP_000244772.1
Coordinates 3066943..3067350 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag COG34_RS15935 Protein ID WP_000354046.1
Coordinates 3066696..3066962 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
COG34_RS15910 3061984..3062727 + 744 WP_000951964.1 SDR family oxidoreductase -
COG34_RS15915 3062784..3064217 - 1434 WP_001363803.1 6-phospho-beta-glucosidase BglA -
COG34_RS15920 3064262..3064573 + 312 WP_001182944.1 N(4)-acetylcytidine aminohydrolase -
COG34_RS15925 3064737..3065396 + 660 WP_000250274.1 hemolysin III family protein -
COG34_RS15930 3065473..3066453 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
COG34_RS15935 3066696..3066962 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
COG34_RS15940 3066943..3067350 + 408 WP_000244772.1 protein YgfX Toxin
COG34_RS15945 3067390..3067911 - 522 WP_001055874.1 flavodoxin FldB -
COG34_RS15950 3068023..3068919 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
COG34_RS15955 3068944..3069654 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
COG34_RS15960 3069660..3071393 + 1734 WP_000813215.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16048.02 Da        Isoelectric Point: 11.2511

>T87235 WP_000244772.1 NZ_CP024243:3066943-3067350 [Escherichia coli O128:H27]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T87235 NZ_CP024243:3066943-3067350 [Escherichia coli O128:H27]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT87235 WP_000354046.1 NZ_CP024243:3066696-3066962 [Escherichia coli O128:H27]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT87235 NZ_CP024243:3066696-3066962 [Escherichia coli O128:H27]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XYB4

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References