Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2271631..2272463 Replicon chromosome
Accession NZ_CP024240
Organism Escherichia coli O114:H49 strain 90-9280

Toxin (Protein)


Gene name yeeV Uniprot ID S1PD64
Locus tag COG33_RS12105 Protein ID WP_000854753.1
Coordinates 2272089..2272463 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID E3PJ72
Locus tag COG33_RS12100 Protein ID WP_001278232.1
Coordinates 2271631..2271999 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
COG33_RS12065 2268450..2268905 + 456 WP_000581504.1 hypothetical protein -
COG33_RS12070 2268984..2269217 + 234 WP_001119729.1 DUF905 family protein -
COG33_RS12080 2269317..2270135 + 819 WP_001234631.1 DUF945 domain-containing protein -
COG33_RS12085 2270217..2270696 + 480 WP_000860064.1 antirestriction protein -
COG33_RS12090 2270708..2271184 + 477 WP_001186710.1 RadC family protein -
COG33_RS12095 2271247..2271468 + 222 WP_000692303.1 DUF987 domain-containing protein -
COG33_RS12100 2271631..2271999 + 369 WP_001278232.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
COG33_RS12105 2272089..2272463 + 375 WP_000854753.1 TA system toxin CbtA family protein Toxin
COG33_RS12110 2272460..2272948 + 489 WP_000777541.1 hypothetical protein -
COG33_RS12115 2272960..2273157 + 198 WP_000839281.1 DUF957 domain-containing protein -
COG33_RS12120 2273254..2273823 + 570 WP_001290243.1 DUF4942 domain-containing protein -
COG33_RS12125 2274104..2274640 - 537 WP_000942795.1 GspM family type II secretion system protein YghD -
COG33_RS12130 2274642..2275820 - 1179 WP_000094974.1 type II secretion system protein GspL -
COG33_RS12135 2275817..2276794 - 978 WP_000633220.1 type II secretion system minor pseudopilin GspK -
COG33_RS12140 2276797..2277396 - 600 WP_001255040.1 type II secretion system minor pseudopilin GspJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14005.00 Da        Isoelectric Point: 8.2905

>T87211 WP_000854753.1 NZ_CP024240:2272089-2272463 [Escherichia coli O114:H49]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

>T87211 NZ_CP024240:2272089-2272463 [Escherichia coli O114:H49]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13491.37 Da        Isoelectric Point: 6.6290

>AT87211 WP_001278232.1 NZ_CP024240:2271631-2271999 [Escherichia coli O114:H49]
VSDALSGTMLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT87211 NZ_CP024240:2271631-2271999 [Escherichia coli O114:H49]
GTGTCAGACGCACTCTCCGGGACAATGCTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGTCTGACCTGCAAAGCTGACACTCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LVU0

Antitoxin

Source ID Structure
AlphaFold DB E3PJ72

References