Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4848386..4849230 Replicon chromosome
Accession NZ_CP024239
Organism Escherichia coli O15:H11 strain 90-9272

Toxin (Protein)


Gene name yeeV Uniprot ID B1LJY4
Locus tag COG31_RS27045 Protein ID WP_000854686.1
Coordinates 4848847..4849230 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A8E0J1S3
Locus tag COG31_RS27040 Protein ID WP_001285602.1
Coordinates 4848386..4848766 (+) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
COG31_RS27000 (4844635) 4844635..4845090 + 456 WP_001504120.1 IrmA family protein -
COG31_RS27005 (4845169) 4845169..4845402 + 234 WP_001119717.1 DUF905 family protein -
COG31_RS27015 (4845502) 4845502..4846320 + 819 WP_001234732.1 DUF932 domain-containing protein -
COG31_RS27020 (4846412) 4846412..4846897 + 486 WP_000214307.1 antirestriction protein -
COG31_RS27025 (4846913) 4846913..4847389 + 477 WP_001186726.1 RadC family protein -
COG31_RS27030 (4847452) 4847452..4847673 + 222 WP_000692298.1 DUF987 domain-containing protein -
COG31_RS27035 (4847692) 4847692..4848375 + 684 WP_000086768.1 hypothetical protein -
COG31_RS27040 (4848386) 4848386..4848766 + 381 WP_001285602.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
COG31_RS27045 (4848847) 4848847..4849230 + 384 WP_000854686.1 TA system toxin CbtA family protein Toxin
COG31_RS27050 (4849227) 4849227..4849715 + 489 WP_001054233.1 DUF5983 family protein -
COG31_RS27055 (4849732) 4849732..4849929 + 198 WP_000839253.1 DUF957 domain-containing protein -
COG31_RS27060 (4850014) 4850014..4850856 + 843 WP_001431817.1 DUF4942 domain-containing protein -
COG31_RS27070 (4851327) 4851327..4852265 + 939 WP_001468571.1 glyoxylate/hydroxypyruvate reductase GhrA -
COG31_RS27075 (4852320) 4852320..4853057 + 738 WP_000283667.1 zinc-binding phosphatase -
COG31_RS27080 (4853081) 4853081..4853635 + 555 WP_001001921.1 molecular chaperone YcdY -
COG31_RS27085 (4853737) 4853737..4854228 + 492 WP_001300785.1 DUF1097 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-113)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14272.28 Da        Isoelectric Point: 6.8614

>T87197 WP_000854686.1 NZ_CP024239:4848847-4849230 [Escherichia coli O15:H11]
MKTLPDTHVRAASRCPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGAPSSQLINSIDILRARRATGLMTRDNYRMVNNITLGKHPEEAKQ

Download         Length: 384 bp

>T87197 NZ_CP024239:4848847-4849230 [Escherichia coli O15:H11]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTTACGTTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGTGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGTCTCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCG
GGACAATTACAGAATGGTAAATAACATTACCCTGGGCAAGCATCCGGAGGAGGCGAAACAATGA

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 13938.69 Da        Isoelectric Point: 5.0823

>AT87197 WP_001285602.1 NZ_CP024239:4848386-4848766 [Escherichia coli O15:H11]
VSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Download         Length: 381 bp

>AT87197 NZ_CP024239:4848386-4848766 [Escherichia coli O15:H11]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAACAAAGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGGCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTCCGGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References