Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 3692297..3693165 | Replicon | chromosome |
| Accession | NZ_CP024239 | ||
| Organism | Escherichia coli O15:H11 strain 90-9272 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | - |
| Locus tag | COG31_RS21030 | Protein ID | WP_099550826.1 |
| Coordinates | 3692297..3692707 (-) | Length | 137 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | COG31_RS21035 | Protein ID | WP_032256355.1 |
| Coordinates | 3692797..3693165 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| COG31_RS21000 (3687668) | 3687668..3689168 | + | 1501 | Protein_3516 | IS21-like element ISEc10 family transposase | - |
| COG31_RS21005 (3689165) | 3689165..3689920 | + | 756 | WP_000065240.1 | IS21-like element ISEc10 family helper ATPase IstB | - |
| COG31_RS28495 (3689969) | 3689969..3690259 | - | 291 | WP_072001024.1 | hypothetical protein | - |
| COG31_RS28500 (3690253) | 3690253..3690630 | - | 378 | WP_072001025.1 | CSS-motif domain-containing protein | - |
| COG31_RS21015 (3690701) | 3690701..3691546 | - | 846 | WP_032256362.1 | DUF4942 domain-containing protein | - |
| COG31_RS21020 (3691631) | 3691631..3691828 | - | 198 | WP_032256361.1 | DUF957 domain-containing protein | - |
| COG31_RS21025 (3691846) | 3691846..3692334 | - | 489 | WP_032256359.1 | DUF5983 family protein | - |
| COG31_RS21030 (3692297) | 3692297..3692707 | - | 411 | WP_099550826.1 | TA system toxin CbtA family protein | Toxin |
| COG31_RS21035 (3692797) | 3692797..3693165 | - | 369 | WP_032256355.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| COG31_RS21040 (3693215) | 3693215..3693856 | - | 642 | WP_032256353.1 | hypothetical protein | - |
| COG31_RS21045 (3693875) | 3693875..3694096 | - | 222 | WP_000692303.1 | DUF987 domain-containing protein | - |
| COG31_RS21050 (3694165) | 3694165..3694641 | - | 477 | WP_032256351.1 | RadC family protein | - |
| COG31_RS21055 (3694656) | 3694656..3695141 | - | 486 | WP_000206661.1 | antirestriction protein | - |
| COG31_RS21060 (3695233) | 3695233..3696051 | - | 819 | WP_032256350.1 | DUF932 domain-containing protein | - |
| COG31_RS21070 (3696151) | 3696151..3696384 | - | 234 | WP_032256349.1 | DUF905 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | rfaE / gspC / gspD / gspE / gspF / gspG / gspH / gspI / gspJ / gspK / gspL / gspM / vipA/tssB / vipB/tssC / hcp/tssD / clpV/tssH / lpxD / lpxA | 3567983..3817166 | 249183 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 137 a.a. Molecular weight: 15260.14 Da Isoelectric Point: 7.3529
>T87194 WP_099550826.1 NZ_CP024239:c3692707-3692297 [Escherichia coli O15:H11]
MNTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIETGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGRNNETGSDAGSRQH
MNTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIETGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGRNNETGSDAGSRQH
Download Length: 411 bp
>T87194 NZ_CP024239:c3692707-3692297 [Escherichia coli O15:H11]
ATGAACACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTAAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AGACAGGCATTTCACTCTGTGATGCAGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGCGAAACAATGAAACTGGCTCTGACGCTGGAAGCC
GACAGCATTAA
ATGAACACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTAAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AGACAGGCATTTCACTCTGTGATGCAGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGCGAAACAATGAAACTGGCTCTGACGCTGGAAGCC
GACAGCATTAA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13715.44 Da Isoelectric Point: 5.8808
>AT87194 WP_032256355.1 NZ_CP024239:c3693165-3692797 [Escherichia coli O15:H11]
VSDSLHETNYPDDHNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK
VSDSLHETNYPDDHNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK
Download Length: 369 bp
>AT87194 NZ_CP024239:c3693165-3692797 [Escherichia coli O15:H11]
GTGTCAGACTCGCTCCATGAGACAAATTATCCCGACGACCATAACGACCGCCCCTGGTGGGGACTGCCCTGCACCGTGAC
ACCCTGTTTTGGCGCCCGTCTGGTGCAGGAAGGCAACCAGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTCAGCCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
GTGTCAGACTCGCTCCATGAGACAAATTATCCCGACGACCATAACGACCGCCCCTGGTGGGGACTGCCCTGCACCGTGAC
ACCCTGTTTTGGCGCCCGTCTGGTGCAGGAAGGCAACCAGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTCAGCCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|