Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 31777..32324 Replicon plasmid unnamed3
Accession NZ_CP024226
Organism Escherichia coli O169:H41 strain 2014EL-1345-2

Toxin (Protein)


Gene name parE Uniprot ID W0LWB3
Locus tag CJV63_RS25730 Protein ID WP_000970007.1
Coordinates 31777..32058 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E1QMW3
Locus tag CJV63_RS25735 Protein ID WP_000079941.1
Coordinates 32055..32324 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CJV63_RS25700 28404..29006 + 603 WP_000517695.1 hypothetical protein -
CJV63_RS25705 29062..29556 + 495 WP_001459505.1 hypothetical protein -
CJV63_RS27480 29556..29822 + 267 WP_000955263.1 hypothetical protein -
CJV63_RS25720 30299..30772 - 474 WP_001334658.1 hypothetical protein -
CJV63_RS25725 30889..31737 - 849 WP_001057996.1 3'-5' exonuclease -
CJV63_RS25730 31777..32058 - 282 WP_000970007.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CJV63_RS25735 32055..32324 - 270 WP_000079941.1 hypothetical protein Antitoxin
CJV63_RS27485 32379..32537 - 159 WP_000841008.1 hypothetical protein -
CJV63_RS25750 33234..34265 - 1032 WP_000907882.1 replication initiation protein -
CJV63_RS25765 34968..35609 + 642 WP_000335851.1 transcription termination factor NusG -
CJV63_RS25770 35750..36415 + 666 WP_000154140.1 hypothetical protein -
CJV63_RS25780 36686..36916 + 231 WP_071596634.1 PilI type IV pilus biogenesis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaCTX-M-15 / qnrS1 - 1..85864 85864


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10892.63 Da        Isoelectric Point: 9.7617

>T87108 WP_000970007.1 NZ_CP024226:c32058-31777 [Escherichia coli O169:H41]
MMEIFWTMLASQDRKRIRKYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKV
YILRVLHTAQKWP

Download         Length: 282 bp

>T87108 NZ_CP024226:c32058-31777 [Escherichia coli O169:H41]
ATGATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTAAGTACATTGCGGAGCAGAACCTGAT
GGCCGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTC
GTGTGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTG
TATATCCTGCGCGTGTTGCATACTGCACAGAAGTGGCCATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10252.58 Da        Isoelectric Point: 7.2057

>AT87108 WP_000079941.1 NZ_CP024226:c32324-32055 [Escherichia coli O169:H41]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp

>AT87108 NZ_CP024226:c32324-32055 [Escherichia coli O169:H41]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATTCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
AGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCCGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAGGTTGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7G1GDN5

Antitoxin

Source ID Structure
AlphaFold DB A0A629TXC5

References