Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 549775..550411 Replicon chromosome
Accession NZ_CP024204
Organism Bacillus altitudinis strain P-10

Toxin (Protein)


Gene name mazF Uniprot ID K2MHT4
Locus tag CSE15_RS02710 Protein ID WP_003214169.1
Coordinates 550061..550411 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID W8QJ31
Locus tag CSE15_RS02705 Protein ID WP_003214273.1
Coordinates 549775..550056 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSE15_RS02685 545930..546535 - 606 WP_007496491.1 rhomboid family intramembrane serine protease -
CSE15_RS02690 546630..546995 + 366 WP_017366663.1 holo-ACP synthase -
CSE15_RS02695 547155..548171 + 1017 WP_007496489.1 outer membrane lipoprotein-sorting protein -
CSE15_RS02700 548300..549481 + 1182 WP_099496334.1 alanine racemase -
CSE15_RS02705 549775..550056 + 282 WP_003214273.1 hypothetical protein Antitoxin
CSE15_RS02710 550061..550411 + 351 WP_003214169.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
CSE15_RS02715 550528..551358 + 831 WP_008346908.1 RsbT co-antagonist protein RsbRA -
CSE15_RS02720 551363..551731 + 369 WP_003214235.1 RsbT antagonist protein RsbS -
CSE15_RS02725 551734..552135 + 402 WP_019744214.1 anti-sigma regulatory factor -
CSE15_RS02730 552146..553153 + 1008 WP_074041673.1 PP2C family protein-serine/threonine phosphatase -
CSE15_RS02735 553213..553542 + 330 WP_019744215.1 anti-sigma factor antagonist -
CSE15_RS02740 553539..554027 + 489 WP_019744216.1 anti-sigma B factor RsbW -
CSE15_RS02745 553993..554781 + 789 WP_012009000.1 RNA polymerase sigma factor SigB -
CSE15_RS02750 554781..555380 + 600 WP_024719202.1 SpoIIE family protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12976.99 Da        Isoelectric Point: 5.1663

>T87089 WP_003214169.1 NZ_CP024204:550061-550411 [Bacillus altitudinis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEINAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDEALQVSLALIDF

Download         Length: 351 bp

>T87089 NZ_CP024204:550061-550411 [Bacillus altitudinis]
TTGATTGTTAAACGCGGTGATGTTTACTTTGCTGATTTATCTCCTGTTGTTGGCTCCGAGCAGGGCGGGGTTCGCCCGGT
ATTGGTGATTCAAAATGACATTGGAAATCGCTTCAGCCCGACTGCTATCGTTGCAGCCATAACAGCCCAAATACAAAAAG
CGAAATTACCGACTCACGTCGAAATTAATGCAAAGCGCTACGGCTTTGAACGAGATTCTGTCATTCTTTTGGAACAGATT
CGTACAATCGATAAACAAAGATTGACAGATAAAATCACACATCTTGATGATGAGATGATGGAGAAGGTTGATGAAGCCTT
ACAAGTTAGTTTGGCTCTTATTGATTTTTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10864.25 Da        Isoelectric Point: 5.2726

>AT87089 WP_003214273.1 NZ_CP024204:549775-550056 [Bacillus altitudinis]
MSESSATNEMKIRLPEALMSEIERVAEQDKVTRNELIYRATKTYIRERNIRQNRESMRRGYMEMAKINLNISSEAQYAEF
EAENTVERLVSGG

Download         Length: 282 bp

>AT87089 NZ_CP024204:549775-550056 [Bacillus altitudinis]
TTGTCTGAATCCAGCGCAACAAATGAAATGAAGATTCGACTGCCGGAGGCTTTAATGTCTGAGATCGAACGAGTAGCAGA
GCAGGATAAGGTAACAAGAAATGAATTGATCTACCGAGCGACAAAAACGTATATTCGTGAACGTAATATTCGACAAAATC
GTGAATCGATGAGACGCGGCTACATGGAGATGGCGAAAATTAATCTGAATATCTCTTCAGAGGCACAATACGCAGAATTT
GAGGCTGAGAATACAGTTGAGCGATTAGTCAGCGGGGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K2MHT4

Antitoxin

Source ID Structure
AlphaFold DB A0A081L854

References