Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 5458286..5458925 Replicon chromosome
Accession NZ_CP024190
Organism Mycobacterium marinum strain CCUG20998

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID A0A2Z5YL42
Locus tag CCUG20998_RS22915 Protein ID WP_020729617.1
Coordinates 5458286..5458732 (-) Length 149 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID B2HEJ8
Locus tag CCUG20998_RS22920 Protein ID WP_011738542.1
Coordinates 5458737..5458925 (-) Length 63 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCUG20998_RS22890 5453461..5454981 + 1521 WP_020729620.1 carotenoid oxygenase family protein -
CCUG20998_RS22895 5454998..5455471 + 474 WP_012396158.1 VOC family protein -
CCUG20998_RS22900 5455477..5455911 - 435 WP_012396159.1 hypothetical protein -
CCUG20998_RS22905 5455982..5456755 - 774 WP_020729619.1 VOC family protein -
CCUG20998_RS22910 5456924..5458174 + 1251 WP_036456440.1 hypothetical protein -
CCUG20998_RS22915 5458286..5458732 - 447 WP_020729617.1 SRPBCC family protein Toxin
CCUG20998_RS22920 5458737..5458925 - 189 WP_011738542.1 antitoxin Antitoxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-50)


Sequences

Toxin        


Download         Length: 149 a.a.        Molecular weight: 15851.39 Da        Isoelectric Point: 8.6574

>T87059 WP_020729617.1 NZ_CP024190:c5458732-5458286 [Mycobacterium marinum]
MAKLSGSIDVPLSPDEAWMHASDLSRFKEWLTIHRVWRSTLPETLEKGAVVESIVQVKGMHNRIKWTIVRYQPPEGMTLN
GDGVGGVKVKLMAKVAAGEEGSVVSFDVHLGGPALFGPIGMVVAAALRTDINASLRNFVTVFAPSAAG

Download         Length: 447 bp

>T87059 NZ_CP024190:c5458732-5458286 [Mycobacterium marinum]
ATGGCGAAACTTTCCGGGTCGATCGACGTGCCGCTGTCTCCGGACGAGGCATGGATGCACGCATCCGATCTCTCCCGCTT
CAAGGAGTGGCTGACGATCCACCGAGTGTGGCGCAGCACGTTGCCCGAAACCCTCGAAAAGGGTGCGGTCGTCGAATCAA
TCGTGCAGGTCAAGGGCATGCACAACCGCATCAAATGGACCATCGTGCGCTACCAGCCGCCGGAAGGCATGACCCTCAAC
GGTGACGGGGTCGGCGGCGTCAAGGTCAAGCTGATGGCCAAGGTTGCAGCCGGAGAAGAAGGCTCGGTCGTCAGCTTCGA
CGTGCACCTTGGTGGGCCGGCTCTGTTCGGTCCGATCGGCATGGTCGTCGCCGCGGCGCTGCGCACCGATATCAACGCAT
CGCTGCGGAACTTCGTCACCGTATTCGCCCCGTCGGCCGCCGGCTAA

Antitoxin


Download         Length: 63 a.a.        Molecular weight: 6586.35 Da        Isoelectric Point: 4.7205

>AT87059 WP_011738542.1 NZ_CP024190:c5458925-5458737 [Mycobacterium marinum]
MGILDKAKDLLAQNADKVETVIDKAGEFVDEKTEGKYSDTIHKVQEGAKKVAGPGAAGEQQN

Download         Length: 189 bp

>AT87059 NZ_CP024190:c5458925-5458737 [Mycobacterium marinum]
ATGGGAATCCTGGACAAGGCGAAAGACCTGCTGGCGCAGAACGCCGACAAGGTCGAGACGGTGATCGACAAGGCCGGCGA
ATTCGTCGACGAGAAGACCGAGGGGAAGTACTCCGACACCATCCACAAGGTGCAAGAGGGGGCCAAGAAAGTCGCTGGTC
CCGGCGCCGCGGGCGAGCAGCAGAACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2Z5YL42

Antitoxin

Source ID Structure
AlphaFold DB A0A7I7LB02

References