Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 3423665..3424200 Replicon chromosome
Accession NZ_CP024190
Organism Mycobacterium marinum strain CCUG20998

Toxin (Protein)


Gene name mazF Uniprot ID A0A2Z5YH00
Locus tag CCUG20998_RS14450 Protein ID WP_036455701.1
Coordinates 3423868..3424200 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A7I7LGS6
Locus tag CCUG20998_RS14445 Protein ID WP_036455700.1
Coordinates 3423665..3423871 (+) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCUG20998_RS14425 3418983..3419801 + 819 WP_020729182.1 ParA family protein -
CCUG20998_RS14430 3419894..3420721 - 828 WP_020729183.1 DUF1906 domain-containing protein -
CCUG20998_RS14435 3421049..3422734 - 1686 WP_020729184.1 GMC family oxidoreductase N-terminal domain-containing protein -
CCUG20998_RS14440 3422982..3423332 - 351 WP_020729185.1 cupin domain-containing protein -
CCUG20998_RS14445 3423665..3423871 + 207 WP_036455700.1 DUF3018 family protein Antitoxin
CCUG20998_RS14450 3423868..3424200 + 333 WP_036455701.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
CCUG20998_RS14455 3424807..3425148 + 342 WP_036455938.1 DUF2384 domain-containing protein -
CCUG20998_RS14460 3425149..3425703 + 555 WP_020729188.1 RES domain-containing protein -
CCUG20998_RS14465 3425982..3426215 + 234 WP_020729189.1 hypothetical protein -
CCUG20998_RS14470 3426205..3426516 + 312 WP_020729190.1 type II toxin-antitoxin system PemK/MazF family toxin -
CCUG20998_RS14475 3427028..3427699 + 672 WP_020729192.1 hypothetical protein -
CCUG20998_RS28130 3427738..3428421 + 684 WP_020729193.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-105)

Antitoxin

Antitoxin MazE-like

(4-66)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11841.67 Da        Isoelectric Point: 7.3196

>T87058 WP_036455701.1 NZ_CP024190:3423868-3424200 [Mycobacterium marinum]
VNRGEIWTVAGGVYATKPHPAVIVQDDLFDATSSVTVAPMSSTLLDAPLMRIRIAGGDGRLSGLDHNSDVMIDKLTTVKR
SNVHARVGRLTAEQVVEVERVMMAFLGLAR

Download         Length: 333 bp

>T87058 NZ_CP024190:3423868-3424200 [Mycobacterium marinum]
GTGAATAGAGGGGAGATCTGGACCGTAGCGGGGGGCGTCTACGCGACCAAACCGCATCCCGCGGTGATTGTTCAGGATGA
TCTCTTTGATGCCACGAGTTCGGTGACGGTTGCTCCGATGTCCAGCACCCTGTTGGATGCGCCGTTGATGCGCATCCGAA
TAGCCGGCGGAGACGGCCGGTTATCCGGACTTGATCACAACAGTGACGTGATGATCGACAAGCTCACAACCGTGAAAAGG
TCGAACGTCCATGCCCGAGTCGGTCGGCTGACAGCGGAGCAAGTCGTCGAGGTCGAGCGAGTGATGATGGCATTCCTCGG
CCTTGCGCGATAG

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7999.86 Da        Isoelectric Point: 4.8359

>AT87058 WP_036455700.1 NZ_CP024190:3423665-3423871 [Mycobacterium marinum]
MAVRDRVGEYRRRMRERGLRPLQVWVPDVRTESFAAEAHRQASLVARADERGDDQDFIEAISTPWDEE

Download         Length: 207 bp

>AT87058 NZ_CP024190:3423665-3423871 [Mycobacterium marinum]
ATGGCGGTTAGGGACAGGGTCGGCGAGTACCGACGGCGGATGCGGGAGCGGGGCCTGCGGCCGCTGCAGGTCTGGGTGCC
TGACGTGCGCACTGAGAGTTTTGCTGCCGAGGCGCATCGTCAGGCTTCGTTGGTCGCACGAGCGGACGAACGCGGCGATG
ATCAGGACTTCATTGAGGCCATCTCGACGCCATGGGATGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2Z5YH00

Antitoxin

Source ID Structure
AlphaFold DB A0A7I7LGS6

References