Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 2981842..2982503 Replicon chromosome
Accession NZ_CP024175
Organism Bordetella bronchiseptica strain A345

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CS343_RS14015 Protein ID WP_033459448.1
Coordinates 2982078..2982503 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CS343_RS14010 Protein ID WP_003812071.1
Coordinates 2981842..2982081 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CS343_RS13975 2976877..2977680 - 804 WP_003817085.1 bacteriocin family protein -
CS343_RS13980 2977677..2978723 - 1047 WP_003817082.1 Dyp-type peroxidase -
CS343_RS13985 2978801..2979361 - 561 WP_033459449.1 DUF488 domain-containing protein -
CS343_RS13990 2979358..2979591 - 234 WP_033448627.1 DUF2945 domain-containing protein -
CS343_RS13995 2979672..2980184 - 513 WP_033448625.1 redoxin domain-containing protein -
CS343_RS14000 2980243..2980788 - 546 WP_003817079.1 peroxidase-related enzyme -
CS343_RS14005 2980926..2981768 + 843 WP_033448622.1 AraC family transcriptional regulator -
CS343_RS14010 2981842..2982081 + 240 WP_003812071.1 Arc family DNA-binding protein Antitoxin
CS343_RS14015 2982078..2982503 + 426 WP_033459448.1 PIN domain-containing protein Toxin
CS343_RS14020 2982613..2983077 + 465 WP_003812075.1 MarR family transcriptional regulator -
CS343_RS14025 2983185..2984690 - 1506 WP_033840401.1 tripartite tricarboxylate transporter permease -
CS343_RS14030 2985175..2985687 + 513 WP_033456887.1 hypothetical protein -
CS343_RS14035 2985707..2986684 - 978 WP_003817071.1 tripartite tricarboxylate transporter substrate binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-121)

Antitoxin

Arc-like DNA binding domain

(9-46)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 14873.23 Da        Isoelectric Point: 6.3721

>T87051 WP_033459448.1 NZ_CP024175:2982078-2982503 [Bordetella bronchiseptica]
MILLDTDVLLEPLRPAPDPAVAAWLDAQHVETLYLAAPGAAEIQLGLARLPRGKRAEALRHEFERRILPLFMGHVLPFDA
AAADAYAAVMMRAAAAGHALCATDGYIAAIATAHGLAIATRHPARFEAAGLTAVDPWHAAA

Download         Length: 426 bp

>T87051 NZ_CP024175:2982078-2982503 [Bordetella bronchiseptica]
ATGATCCTGCTCGACACCGACGTGCTGCTCGAACCGCTGCGGCCGGCCCCCGACCCGGCCGTCGCGGCATGGCTGGATGC
CCAGCACGTCGAAACCCTGTACCTGGCCGCGCCCGGCGCGGCCGAAATCCAGCTCGGGCTGGCCCGTCTGCCGCGCGGCA
AGCGGGCCGAGGCCCTGCGCCACGAATTCGAGCGGCGCATCCTGCCGCTGTTCATGGGCCATGTCCTGCCTTTCGACGCG
GCCGCGGCCGATGCCTACGCCGCCGTCATGATGCGGGCCGCGGCGGCGGGCCATGCGCTGTGCGCGACCGATGGCTACAT
CGCCGCCATCGCCACCGCGCACGGCCTGGCCATCGCCACGCGCCATCCGGCCAGGTTCGAGGCGGCCGGGCTCACTGCCG
TCGATCCCTGGCACGCCGCCGCTTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8561.78 Da        Isoelectric Point: 11.5658

>AT87051 WP_003812071.1 NZ_CP024175:2981842-2982081 [Bordetella bronchiseptica]
VSSITVRNVPEEVHRALRVRAATHGRSTEAEIRAILENAVLPDGRVKLGTLLSHIGRGARGMDLTIERNPAPARPASFE

Download         Length: 240 bp

>AT87051 NZ_CP024175:2981842-2982081 [Bordetella bronchiseptica]
GTGTCTTCGATTACGGTAAGAAATGTTCCCGAGGAAGTGCATCGCGCCTTGCGCGTACGCGCGGCCACGCATGGGCGCAG
CACCGAGGCCGAGATCCGCGCCATCCTGGAAAACGCCGTGCTGCCCGATGGCCGCGTCAAGCTGGGCACCCTGCTCAGCC
ACATCGGCCGCGGCGCGCGCGGCATGGACCTGACCATCGAGCGCAATCCGGCGCCCGCCCGCCCGGCCAGCTTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References