Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1613601..1614195 Replicon chromosome
Accession NZ_CP024175
Organism Bordetella bronchiseptica strain A345

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag CS343_RS07630 Protein ID WP_033458541.1
Coordinates 1614013..1614195 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag CS343_RS07625 Protein ID WP_003819880.1
Coordinates 1613601..1613990 (-) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CS343_RS07600 1609443..1610483 + 1041 WP_003809635.1 phosphate ABC transporter substrate-binding protein PstS -
CS343_RS07605 1610618..1611634 + 1017 WP_003809636.1 phosphate ABC transporter permease subunit PstC -
CS343_RS07610 1611656..1612513 + 858 WP_003809638.1 phosphate ABC transporter permease PstA -
CS343_RS07615 1612558..1613334 + 777 WP_033448479.1 phosphate ABC transporter ATP-binding protein PstB -
CS343_RS07625 1613601..1613990 - 390 WP_003819880.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CS343_RS07630 1614013..1614195 - 183 WP_033458541.1 type II toxin-antitoxin system HicA family toxin Toxin
CS343_RS07635 1614603..1615301 + 699 WP_003809653.1 gluconate 2-dehydrogenase subunit 3 family protein -
CS343_RS07640 1615305..1617074 + 1770 WP_004568200.1 GMC family oxidoreductase -
CS343_RS07645 1617085..1618440 + 1356 WP_033458538.1 cytochrome c -
CS343_RS07650 1618452..1619192 - 741 WP_050457493.1 carbonic anhydrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-122)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6794.85 Da        Isoelectric Point: 11.1875

>T87050 WP_033458541.1 NZ_CP024175:c1614195-1614013 [Bordetella bronchiseptica]
MNSADLIKQLKADGWYRVHTVGSHHQYKHPTKPGKVTVPHPRKDLPTATQRSILKQAGLR

Download         Length: 183 bp

>T87050 NZ_CP024175:c1614195-1614013 [Bordetella bronchiseptica]
ATGAACAGCGCAGACCTGATCAAGCAACTGAAGGCCGACGGCTGGTATCGCGTGCATACCGTGGGTTCACACCACCAGTA
CAAGCACCCGACCAAGCCCGGCAAGGTCACCGTGCCGCATCCCAGGAAGGACCTGCCGACAGCGACACAGCGCAGCATCC
TTAAGCAAGCCGGCCTGCGATAA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 14300.00 Da        Isoelectric Point: 4.3864

>AT87050 WP_003819880.1 NZ_CP024175:c1613990-1613601 [Bordetella bronchiseptica]
MLYPIHVSKDEGSAYGAVFPDFPGCFAAADELQDLPRAAQEAVEAHFYGETERIPAPSAPEAWANDEDYRGGYWMMVDID
LSKVSTKAVRLNISLPENLVHRIDEEAKARRLSRSAFLAMAAEHEMADA

Download         Length: 390 bp

>AT87050 NZ_CP024175:c1613990-1613601 [Bordetella bronchiseptica]
ATGCTCTACCCGATCCATGTTTCCAAAGACGAAGGCAGCGCCTACGGGGCCGTCTTCCCTGATTTTCCCGGCTGCTTTGC
AGCCGCCGATGAACTCCAGGACCTCCCCCGCGCGGCGCAGGAAGCCGTTGAGGCGCACTTCTACGGAGAGACCGAGCGTA
TCCCCGCCCCGTCCGCCCCGGAAGCGTGGGCCAACGATGAGGACTATCGAGGCGGCTATTGGATGATGGTCGATATCGAC
CTGTCGAAGGTCAGCACGAAGGCCGTGCGGCTCAACATCAGCCTGCCGGAAAACCTGGTTCACCGTATCGACGAGGAAGC
CAAGGCACGACGCCTTTCGCGCTCAGCGTTTCTGGCCATGGCTGCGGAACACGAAATGGCCGACGCCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References