Detailed information of TA system TA087043

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 2874976..2875637
• Replicon: chromosome
• Accession: NZ_CP024173
• Organism: Bordetella bronchiseptica strain D987

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A0C6NZK6
• Locus tag: CS345_RS13575
• Protein ID: WP_003817075.1
• Coordinates: 2875212..2875637 (+)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: CS345_RS13570
• Protein ID: WP_003812071.1
• Coordinates: 2874976..2875215 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CS345_RS13535	2870004..2870807	-	804	WP_015063708.1	bacteriocin family protein	-
CS345_RS13540	2870804..2871850	-	1047	WP_015063707.1	Dyp-type peroxidase	-
CS345_RS13545	2871928..2872488	-	561	WP_015063706.1	DUF488 domain-containing protein	-
CS345_RS13550	2872485..2872718	-	234	WP_033450420.1	DUF2945 domain-containing protein	-
CS345_RS13555	2872800..2873312	-	513	WP_015063705.1	redoxin domain-containing protein	-
CS345_RS13560	2873371..2873916	-	546	WP_015063704.1	peroxidase-related enzyme	-
CS345_RS13565	2874060..2874902	+	843	WP_015063703.1	AraC family transcriptional regulator	-
CS345_RS13570	2874976..2875215	+	240	WP_003812071.1	Arc family DNA-binding protein	Antitoxin
CS345_RS13575	2875212..2875637	+	426	WP_003817075.1	PIN domain-containing protein	Toxin
CS345_RS13580	2875747..2876211	+	465	WP_003812075.1	MarR family transcriptional regulator	-
CS345_RS13585	2876309..2877814	-	1506	WP_015063702.1	tripartite tricarboxylate transporter permease	-
CS345_RS13590	2878304..2878816	+	513	WP_015063701.1	hypothetical protein	-
CS345_RS13595	2878836..2879813	-	978	WP_015041576.1	tripartite tricarboxylate transporter substrate binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-121)

Antitoxin

• Arc-like DNA binding domain (9-46)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 14813.19 Da
• Isoelectric Point: 6.3704

>T87043 WP_003817075.1 NZ_CP024173:2875212-2875637 [Bordetella bronchiseptica]
MILLDTDVLLEPLRPAPDPAVAAWLDAQHVETLYLAAPGAAEIQLGLARLPRGKRAEALRHEFERRILPLFMGHVLPFDA
AAADAYAAVMMRAAAAGHALCATDGCIAAIATAHGLAIATRHPARFEAAGLTAVDPWHAAA

Nucleotide

• Length: 426 bp

>T87043 NZ_CP024173:2875212-2875637 [Bordetella bronchiseptica]
ATGATCCTGCTCGACACCGACGTGCTGCTCGAACCGCTGCGGCCGGCCCCCGACCCGGCCGTCGCGGCATGGCTGGATGC
CCAGCACGTCGAAACCCTGTACCTGGCCGCGCCCGGCGCGGCCGAAATCCAGCTCGGCCTGGCCCGTCTGCCGCGCGGCA
AGCGGGCCGAGGCCCTGCGCCACGAATTCGAGCGGCGCATCCTGCCGCTGTTCATGGGCCATGTCCTGCCTTTCGACGCG
GCCGCGGCCGATGCCTACGCCGCCGTCATGATGCGGGCCGCGGCGGCGGGCCATGCGCTGTGCGCGACCGATGGCTGCAT
CGCCGCCATCGCCACCGCGCACGGGCTGGCCATCGCCACGCGCCATCCGGCCAGGTTCGAGGCGGCCGGGCTCACCGCCG
TCGATCCCTGGCACGCCGCCGCTTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8561.78 Da
• Isoelectric Point: 11.5658

>AT87043 WP_003812071.1 NZ_CP024173:2874976-2875215 [Bordetella bronchiseptica]
VSSITVRNVPEEVHRALRVRAATHGRSTEAEIRAILENAVLPDGRVKLGTLLSHIGRGARGMDLTIERNPAPARPASFE

Nucleotide

• Length: 240 bp

>AT87043 NZ_CP024173:2874976-2875215 [Bordetella bronchiseptica]
GTGTCTTCGATTACGGTAAGAAATGTTCCCGAGGAAGTGCATCGCGCCTTGCGCGTACGCGCGGCCACACATGGGCGCAG
CACCGAGGCCGAGATCCGCGCCATCCTGGAAAACGCCGTGCTGCCCGATGGCCGCGTCAAGCTGGGCACCCTGCTCAGCC
ACATCGGCCGCGGCGCGCGCGGCATGGACCTGACCATCGAGCGCAATCCGGCGCCCGCCCGCCCGGCCAGCTTCGAATGA

Structures

Toxin

• AlphaFold DB: A0A0C6NZK6