Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpA-brnA/BrnT_toxin-BrnA
Location 3168897..3169428 Replicon chromosome
Accession NZ_CP024171
Organism Bordetella bronchiseptica strain D448

Toxin (Protein)


Gene name shpA Uniprot ID A0A0C6P1L1
Locus tag CS344_RS14900 Protein ID WP_015064047.1
Coordinates 3168897..3169163 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID K0MF02
Locus tag CS344_RS14905 Protein ID WP_003816743.1
Coordinates 3169150..3169428 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CS344_RS14875 3164024..3164296 + 273 WP_003812615.1 hypothetical protein -
CS344_RS14880 3164335..3165045 - 711 WP_003812617.1 aquaporin Z -
CS344_RS14885 3165156..3165788 - 633 WP_003812619.1 PAS domain-containing protein -
CS344_RS14890 3166185..3167063 + 879 WP_003812621.1 tripartite tricarboxylate transporter substrate binding protein -
CS344_RS14895 3167125..3168666 + 1542 WP_003812624.1 M81 family metallopeptidase -
CS344_RS14900 3168897..3169163 + 267 WP_015064047.1 BrnT family toxin Toxin
CS344_RS14905 3169150..3169428 + 279 WP_003816743.1 BrnA antitoxin family protein Antitoxin
CS344_RS14915 3169729..3170385 - 657 WP_015064048.1 phosphoribosylanthranilate isomerase -
CS344_RS14920 3170400..3172067 - 1668 WP_003812634.1 TRAP transporter large permease subunit -
CS344_RS14925 3172070..3172699 - 630 WP_003812635.1 TRAP transporter small permease subunit -
CS344_RS14930 3172911..3174005 - 1095 WP_003812637.1 TRAP transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-81)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(12-86)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10090.52 Da        Isoelectric Point: 9.4798

>T87040 WP_015064047.1 NZ_CP024171:3168897-3169163 [Bordetella bronchiseptica]
MDITYDPAKNDKNIADRGLSFELVRGFEWASALVVEDTRQVYAETRYQALGKIDGRLHMVVFTVRGESLRIISLRKANAR
EVARYEKA

Download         Length: 267 bp

>T87040 NZ_CP024171:3168897-3169163 [Bordetella bronchiseptica]
ATGGATATCACCTACGACCCCGCCAAGAACGACAAGAACATTGCCGATCGCGGCCTGTCGTTCGAGTTGGTGCGTGGCTT
CGAGTGGGCCAGCGCGCTGGTGGTTGAGGATACCCGCCAGGTCTACGCCGAAACGCGCTATCAGGCGCTGGGCAAAATCG
ATGGCCGGCTCCATATGGTGGTATTCACGGTGCGCGGCGAGTCGCTGCGCATCATCAGCCTGCGTAAGGCAAATGCTCGT
GAGGTAGCTCGTTATGAAAAAGCCTGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10412.89 Da        Isoelectric Point: 10.5548

>AT87040 WP_003816743.1 NZ_CP024171:3169150-3169428 [Bordetella bronchiseptica]
MKKPDPEKIDRDNPEWTDAEFRRAKPAAEVLPESVHAMLGIRRRGPQKTPTKQVVTIRLSPDVVEAFKASGTGWQTRVDA
ALRDWLKTHQPG

Download         Length: 279 bp

>AT87040 NZ_CP024171:3169150-3169428 [Bordetella bronchiseptica]
ATGAAAAAGCCTGACCCCGAAAAGATTGACCGCGACAACCCCGAATGGACGGACGCGGAATTTCGGCGGGCCAAGCCGGC
CGCCGAAGTACTGCCCGAGTCGGTGCACGCGATGCTCGGCATTCGTCGCCGTGGGCCTCAAAAGACACCCACCAAACAGG
TCGTCACCATCCGGCTATCGCCTGACGTGGTAGAAGCCTTCAAGGCCTCCGGCACCGGTTGGCAGACTCGCGTGGATGCA
GCCCTGCGGGATTGGCTGAAGACGCACCAGCCTGGCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C6P1L1

Antitoxin

Source ID Structure
AlphaFold DB K0MF02

References