Detailed information of TA system TA087039

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 2878812..2879473
• Replicon: chromosome
• Accession: NZ_CP024171
• Organism: Bordetella bronchiseptica strain D448

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A0C6NZK6
• Locus tag: CS344_RS13555
• Protein ID: WP_003817075.1
• Coordinates: 2879048..2879473 (+)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: CS344_RS13550
• Protein ID: WP_003812071.1
• Coordinates: 2878812..2879051 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CS344_RS13515	2873841..2874644	-	804	WP_033447221.1	bacteriocin family protein	-
CS344_RS13520	2874641..2875687	-	1047	WP_003812057.1	Dyp-type peroxidase	-
CS344_RS13525	2875765..2876325	-	561	WP_003812059.1	DUF488 domain-containing protein	-
CS344_RS13530	2876322..2876555	-	234	WP_033447224.1	DUF2945 domain-containing protein	-
CS344_RS13535	2876636..2877148	-	513	WP_015041573.1	redoxin domain-containing protein	-
CS344_RS13540	2877207..2877752	-	546	WP_033447227.1	peroxidase-related enzyme	-
CS344_RS13545	2877896..2878738	+	843	WP_033448622.1	AraC family transcriptional regulator	-
CS344_RS13550	2878812..2879051	+	240	WP_003812071.1	Arc family DNA-binding protein	Antitoxin
CS344_RS13555	2879048..2879473	+	426	WP_003817075.1	PIN domain-containing protein	Toxin
CS344_RS13560	2879583..2880047	+	465	WP_003812075.1	MarR family transcriptional regulator	-
CS344_RS13565	2880145..2881650	-	1506	WP_003812078.1	tripartite tricarboxylate transporter permease	-
CS344_RS13570	2882149..2882661	+	513	WP_003812080.1	hypothetical protein	-
CS344_RS13575	2882682..2883659	-	978	WP_033448428.1	tripartite tricarboxylate transporter substrate binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-121)

Antitoxin

• Arc-like DNA binding domain (9-46)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 14813.19 Da
• Isoelectric Point: 6.3704

>T87039 WP_003817075.1 NZ_CP024171:2879048-2879473 [Bordetella bronchiseptica]
MILLDTDVLLEPLRPAPDPAVAAWLDAQHVETLYLAAPGAAEIQLGLARLPRGKRAEALRHEFERRILPLFMGHVLPFDA
AAADAYAAVMMRAAAAGHALCATDGCIAAIATAHGLAIATRHPARFEAAGLTAVDPWHAAA

Nucleotide

• Length: 426 bp

>T87039 NZ_CP024171:2879048-2879473 [Bordetella bronchiseptica]
ATGATCCTGCTCGACACCGACGTGCTGCTCGAACCGCTGCGGCCGGCCCCCGACCCGGCCGTCGCGGCATGGCTGGATGC
CCAGCACGTCGAAACCCTGTACCTGGCCGCGCCCGGCGCGGCCGAAATCCAGCTCGGCCTGGCCCGTCTGCCGCGCGGCA
AGCGGGCCGAGGCCCTGCGCCACGAATTCGAGCGGCGCATCCTGCCGCTGTTCATGGGCCATGTCCTGCCTTTCGACGCG
GCCGCGGCCGATGCCTACGCCGCCGTCATGATGCGGGCCGCGGCGGCGGGCCATGCGCTGTGCGCGACCGATGGCTGCAT
CGCCGCCATCGCCACCGCGCACGGGCTGGCCATCGCCACGCGCCATCCGGCCAGGTTCGAGGCGGCCGGGCTCACCGCCG
TCGATCCCTGGCACGCCGCCGCTTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8561.78 Da
• Isoelectric Point: 11.5658

>AT87039 WP_003812071.1 NZ_CP024171:2878812-2879051 [Bordetella bronchiseptica]
VSSITVRNVPEEVHRALRVRAATHGRSTEAEIRAILENAVLPDGRVKLGTLLSHIGRGARGMDLTIERNPAPARPASFE

Nucleotide

• Length: 240 bp

>AT87039 NZ_CP024171:2878812-2879051 [Bordetella bronchiseptica]
GTGTCTTCGATTACGGTAAGAAATGTTCCCGAGGAAGTGCATCGCGCCTTGCGCGTACGCGCGGCCACACATGGGCGCAG
CACCGAGGCCGAGATCCGCGCCATCCTGGAAAACGCCGTGCTGCCCGATGGCCGCGTCAAGCTGGGCACCCTGCTCAGCC
ACATCGGCCGCGGCGCGCGCGGCATGGACCTGACCATCGAGCGCAATCCGGCGCCCGCCCGCCCGGCCAGCTTCGAATGA

Structures

Toxin

• AlphaFold DB: A0A0C6NZK6