Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 3678772..3679388 Replicon chromosome
Accession NZ_CP024170
Organism Microbacterium sp. Y-01

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CSX12_RS17695 Protein ID WP_164479600.1
Coordinates 3678772..3679173 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CSX12_RS17700 Protein ID WP_124896665.1
Coordinates 3679170..3679388 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSX12_RS17665 3674378..3675343 - 966 WP_164479637.1 alpha-ketoacid dehydrogenase subunit beta -
CSX12_RS17670 3675355..3676482 - 1128 WP_124896662.1 thiamine pyrophosphate-dependent dehydrogenase E1 component subunit alpha -
CSX12_RS17675 3676589..3677656 - 1068 WP_124896663.1 histidinol-phosphate transaminase -
CSX12_RS17680 3677742..3677948 + 207 WP_164479599.1 ribbon-helix-helix protein, CopG family -
CSX12_RS17685 3677952..3678332 + 381 WP_017203579.1 type II toxin-antitoxin system death-on-curing family toxin -
CSX12_RS17690 3678367..3678771 + 405 WP_017203580.1 phage holin family protein -
CSX12_RS17695 3678772..3679173 - 402 WP_164479600.1 PIN domain nuclease Toxin
CSX12_RS17700 3679170..3679388 - 219 WP_124896665.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
CSX12_RS17705 3679427..3680749 - 1323 WP_124896666.1 hypothetical protein -
CSX12_RS17710 3680746..3680997 - 252 WP_017203585.1 hypothetical protein -
CSX12_RS17715 3681155..3681670 + 516 WP_051000904.1 low molecular weight phosphotyrosine protein phosphatase -
CSX12_RS17720 3681709..3683049 + 1341 WP_206427109.1 adenylosuccinate lyase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-118)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-39)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14491.65 Da        Isoelectric Point: 4.7307

>T87036 WP_164479600.1 NZ_CP024170:c3679173-3678772 [Microbacterium sp. Y-01]
VILVDSSAWIAYLRGDDSPVVERLDALIVADAELAITEPVIMELLAGARTPGERSRVEALANGLRLVPLDPMNDFRDAAD
LYRASAVNGHPIRSMVHCLIAAVAIRRDVVLLHQDHDFGCLSEISPLRVDTGR

Download         Length: 402 bp

>T87036 NZ_CP024170:c3679173-3678772 [Microbacterium sp. Y-01]
GTGATCCTCGTCGACTCATCCGCATGGATCGCCTATCTCCGGGGCGACGACTCGCCCGTCGTGGAACGGCTGGACGCGCT
GATCGTGGCCGACGCGGAACTGGCGATCACGGAGCCCGTGATCATGGAGCTGTTGGCCGGCGCACGCACTCCCGGAGAGC
GGTCGAGGGTCGAGGCGCTCGCGAACGGCCTGCGTCTGGTGCCACTGGACCCGATGAACGACTTCCGGGATGCCGCCGAC
CTCTACCGTGCCTCGGCTGTCAACGGTCACCCGATCCGCAGCATGGTCCACTGCCTGATCGCGGCCGTCGCGATCAGGCG
CGACGTGGTGCTCCTGCACCAGGATCACGACTTCGGCTGCCTCTCGGAGATCAGCCCGCTGCGCGTCGACACAGGGCGTT
GA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8213.32 Da        Isoelectric Point: 4.7584

>AT87036 WP_124896665.1 NZ_CP024170:c3679388-3679170 [Microbacterium sp. Y-01]
MARTNIDIDDDLVREVMRRYDLSTKKEAVELALRRLVGVPLTQDFLRGLRGSGWSGDLDAMRDDPPAPWGRE

Download         Length: 219 bp

>AT87036 NZ_CP024170:c3679388-3679170 [Microbacterium sp. Y-01]
ATGGCCCGCACCAATATCGACATCGACGACGATCTCGTGCGTGAGGTCATGCGGCGCTACGACCTCTCCACGAAGAAGGA
GGCCGTCGAGCTCGCCCTGCGCCGCCTGGTCGGCGTCCCGCTCACCCAGGACTTCCTGCGGGGACTCCGCGGCTCGGGAT
GGAGCGGCGACCTCGACGCGATGCGTGACGACCCGCCGGCGCCATGGGGGCGCGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References