Detailed information of TA system TA087035

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 561996..562585
• Replicon: chromosome
• Accession: NZ_CP024170
• Organism: Microbacterium sp. Y-01

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: CSX12_RS02635
• Protein ID: WP_164479615.1
• Coordinates: 562235..562585 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: CSX12_RS02630
• Protein ID: WP_124894751.1
• Coordinates: 561996..562217 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CSX12_RS02610	557901..558440	-	540	WP_124894748.1	YaeQ family protein	-
CSX12_RS02615	558483..559574	-	1092	WP_124894749.1	Rv2578c family radical SAM protein	-
CSX12_RS02620	559649..560578	+	930	WP_124894750.1	M15 family metallopeptidase	-
CSX12_RS02625	560730..561893	+	1164	WP_017204320.1	acyl-CoA dehydrogenase family protein	-
CSX12_RS02630	561996..562217	+	222	WP_124894751.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
CSX12_RS02635	562235..562585	+	351	WP_164479615.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
CSX12_RS02640	562835..563710	-	876	WP_124894753.1	siderophore-interacting protein	-
CSX12_RS02645	563721..564506	-	786	WP_124896793.1	energy-coupling factor transporter transmembrane protein EcfT	-
CSX12_RS02650	564557..566242	-	1686	WP_124894754.1	energy-coupling factor ABC transporter ATP-binding protein	-
CSX12_RS02655	566314..566859	-	546	WP_124894755.1	ECF transporter S component	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-113)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12299.28 Da
• Isoelectric Point: 10.9436

>T87035 WP_164479615.1 NZ_CP024170:562235-562585 [Microbacterium sp. Y-01]
MLRRGQIVLVAFDPAVGSEARKTRPAVVVSNNTANAAALRSSGATVTVVPVTSHATKVYPFQVKLPAETTGLHHDSKAQA
EQVRTVAVARIVKPVGWVPAELMGAIDETLRLHLAL

Nucleotide

• Length: 351 bp

>T87035 NZ_CP024170:562235-562585 [Microbacterium sp. Y-01]
CTGCTTCGGCGCGGACAGATCGTCCTCGTAGCCTTCGATCCCGCGGTGGGCTCCGAGGCGCGCAAGACCCGCCCGGCCGT
CGTGGTGAGCAACAACACGGCGAACGCTGCGGCCCTGAGGTCGTCGGGGGCCACGGTCACCGTCGTGCCGGTCACGTCCC
ACGCCACGAAGGTCTACCCGTTCCAGGTGAAGCTCCCGGCTGAGACCACGGGGTTGCATCACGATTCCAAGGCGCAGGCG
GAGCAGGTGAGGACGGTGGCGGTCGCGCGCATCGTGAAGCCGGTGGGCTGGGTCCCTGCCGAGCTGATGGGCGCGATCGA
CGAGACCCTCCGCCTGCACCTCGCTCTCTGA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 7736.48 Da
• Isoelectric Point: 4.1398

>AT87035 WP_124894751.1 NZ_CP024170:561996-562217 [Microbacterium sp. Y-01]
MPTAKVSLSLTAADLAFLDAEALEGRYPSRSAAVHDAVRLLRESRLADAYAEAYAEGHDDEWDTAIGDGLASA

Nucleotide

• Length: 222 bp

>AT87035 NZ_CP024170:561996-562217 [Microbacterium sp. Y-01]
ATGCCTACCGCGAAAGTCAGCCTGAGCCTCACGGCAGCCGACCTCGCCTTCCTCGACGCCGAGGCGCTGGAAGGGCGCTA
TCCGTCCCGCTCGGCGGCAGTGCACGACGCGGTGCGTCTCCTCCGAGAGAGTCGCCTGGCGGATGCCTATGCCGAGGCCT
ACGCCGAGGGCCACGACGACGAATGGGATACCGCGATCGGCGACGGGCTGGCGTCCGCGTGA