Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 37081..37606 Replicon plasmid pCFSAN024441_02
Accession NZ_CP024167
Organism Salmonella enterica subsp. enterica serovar Gaminara strain CFSAN070644

Toxin (Protein)


Gene name ccdB Uniprot ID I3VZQ7
Locus tag CS348_RS25685 Protein ID WP_001159874.1
Coordinates 37081..37386 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID I3VZQ6
Locus tag CS348_RS25690 Protein ID WP_000813642.1
Coordinates 37388..37606 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CS348_RS25655 32756..33094 - 339 WP_024136783.1 hypothetical protein -
CS348_RS25660 33186..33827 - 642 WP_000511282.1 ParA family protein -
CS348_RS25665 34365..35228 + 864 WP_085398053.1 RepB family plasmid replication initiator protein -
CS348_RS25670 35462..36244 - 783 WP_023229695.1 site-specific integrase -
CS348_RS25675 36257..36792 - 536 Protein_47 cytoplasmic protein -
CS348_RS25680 36789..37079 - 291 WP_001266178.1 hypothetical protein -
CS348_RS25685 37081..37386 - 306 WP_001159874.1 type II toxin-antitoxin system toxin CcdB Toxin
CS348_RS25690 37388..37606 - 219 WP_000813642.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
CS348_RS25695 38317..38562 + 246 WP_000368362.1 hypothetical protein -
CS348_RS25700 38567..39529 + 963 WP_023229666.1 hypothetical protein -
CS348_RS25705 39563..39907 + 345 WP_023229667.1 hypothetical protein -
CS348_RS25710 39931..40714 - 784 Protein_54 hypothetical protein -
CS348_RS26245 40956..41133 - 178 Protein_55 Tn3 family transposase -
CS348_RS25715 41197..41526 + 330 Protein_56 5'-nucleotidase, lipoprotein e(P4) family -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..92392 92392


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-96)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 15030.03 Da        Isoelectric Point: 5.5500

>T87034 WP_001159874.1 NZ_CP024167:c37386-37081 [Salmonella enterica subsp. enterica serovar Gaminara]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFF

Download         Length: 306 bp

>T87034 NZ_CP024167:c37386-37081 [Salmonella enterica subsp. enterica serovar Gaminara]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 10761.91 Da        Isoelectric Point: 5.5500

>AT87034 WP_000813642.1 NZ_CP024167:c37606-37388 [Salmonella enterica subsp. enterica serovar Gaminara]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 219 bp

>AT87034 NZ_CP024167:c37606-37388 [Salmonella enterica subsp. enterica serovar Gaminara]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A600Z065

Antitoxin

Source ID Structure
AlphaFold DB A0A600YYQ0

References