Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsxAB/Xre(antitoxin) |
| Location | 36953..37454 | Replicon | plasmid p14EC047a |
| Accession | NZ_CP024156 | ||
| Organism | Escherichia coli strain 14EC047 | ||
Toxin (Protein)
| Gene name | TsxA | Uniprot ID | H1ZXU8 |
| Locus tag | CR540_RS25785 | Protein ID | WP_000702247.1 |
| Coordinates | 36953..37213 (+) | Length | 87 a.a. |
Antitoxin (Protein)
| Gene name | TsxB | Uniprot ID | - |
| Locus tag | CR540_RS25790 | Protein ID | WP_001132407.1 |
| Coordinates | 37203..37454 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CR540_RS25740 (CR540_27110) | 32495..32647 | + | 153 | Protein_40 | DUF5431 family protein | - |
| CR540_RS27910 (CR540_27110) | 32592..32714 | + | 123 | WP_223163518.1 | Hok/Gef family protein | - |
| CR540_RS25745 (CR540_27115) | 32863..33459 | + | 597 | WP_000125165.1 | ProQ/FINO family protein | - |
| CR540_RS27915 | 33477..33761 | - | 285 | WP_001162371.1 | hypothetical protein | - |
| CR540_RS25755 (CR540_27125) | 33835..34511 | - | 677 | Protein_44 | division plane positioning ATPase MipZ | - |
| CR540_RS25765 (CR540_27135) | 35095..35424 | + | 330 | WP_000855120.1 | hypothetical protein | - |
| CR540_RS27350 | 35533..35679 | - | 147 | WP_001356709.1 | hypothetical protein | - |
| CR540_RS25770 (CR540_27145) | 36006..36329 | + | 324 | WP_000427403.1 | hypothetical protein | - |
| CR540_RS25775 (CR540_27150) | 36371..36580 | + | 210 | WP_000866036.1 | hypothetical protein | - |
| CR540_RS25780 (CR540_27155) | 36677..36901 | + | 225 | WP_000814381.1 | hypothetical protein | - |
| CR540_RS25785 (CR540_27160) | 36953..37213 | + | 261 | WP_000702247.1 | hypothetical protein | Toxin |
| CR540_RS25790 (CR540_27165) | 37203..37454 | + | 252 | WP_001132407.1 | transcriptional regulator | Antitoxin |
| CR540_RS25805 (CR540_27180) | 38003..38281 | + | 279 | WP_000545938.1 | hypothetical protein | - |
| CR540_RS25810 (CR540_27185) | 38701..38967 | + | 267 | WP_000681608.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| CR540_RS27920 | 39074..39517 | - | 444 | WP_000068545.1 | hypothetical protein | - |
| CR540_RS25820 (CR540_27195) | 39814..39996 | + | 183 | WP_000833470.1 | type II toxin-antitoxin system HicA family toxin | - |
| CR540_RS25825 (CR540_27200) | 40020..40457 | + | 438 | WP_000466318.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| CR540_RS25830 (CR540_27205) | 40588..40914 | - | 327 | WP_063078684.1 | hypothetical protein | - |
| CR540_RS25835 (CR540_27210) | 40934..41641 | - | 708 | WP_021503228.1 | hypothetical protein | - |
| CR540_RS25840 (CR540_27215) | 41643..42395 | - | 753 | WP_000797966.1 | conjugal transfer protein TraL | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | mcr-1.1 | - | 1..60258 | 60258 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 87 a.a. Molecular weight: 9817.29 Da Isoelectric Point: 10.0665
>T87011 WP_000702247.1 NZ_CP024156:36953-37213 [Escherichia coli]
MKIRKGDRQYYLNKEGDTFHLVKRVKTFSKSATLGKTKATVKTVADLVFHEKAFDTIDFASDGLRENDKEIVSMMIQEMS
EGKNAK
MKIRKGDRQYYLNKEGDTFHLVKRVKTFSKSATLGKTKATVKTVADLVFHEKAFDTIDFASDGLRENDKEIVSMMIQEMS
EGKNAK
Download Length: 261 bp
>T87011 NZ_CP024156:36953-37213 [Escherichia coli]
ATGAAGATAAGAAAAGGTGACAGACAATATTATCTGAATAAAGAAGGTGATACGTTTCATCTGGTGAAGCGAGTAAAAAC
TTTTTCTAAGTCTGCGACTTTAGGAAAAACGAAAGCAACGGTGAAAACTGTTGCCGATCTTGTTTTTCATGAGAAGGCAT
TCGACACTATCGACTTTGCCAGCGACGGATTAAGAGAGAATGATAAAGAAATTGTTTCTATGATGATTCAGGAAATGAGT
GAGGGAAAAAATGCCAAATGA
ATGAAGATAAGAAAAGGTGACAGACAATATTATCTGAATAAAGAAGGTGATACGTTTCATCTGGTGAAGCGAGTAAAAAC
TTTTTCTAAGTCTGCGACTTTAGGAAAAACGAAAGCAACGGTGAAAACTGTTGCCGATCTTGTTTTTCATGAGAAGGCAT
TCGACACTATCGACTTTGCCAGCGACGGATTAAGAGAGAATGATAAAGAAATTGTTTCTATGATGATTCAGGAAATGAGT
GAGGGAAAAAATGCCAAATGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9404.77 Da Isoelectric Point: 9.8120
>AT87011 WP_001132407.1 NZ_CP024156:37203-37454 [Escherichia coli]
MPNENTPENIKRLRQKIGLTQKECAEIFSMSPRTWRRKEEPVGTASGTALTPVEFKFLLLLAGEHPDYVLCKRNKKNSDS
GSN
MPNENTPENIKRLRQKIGLTQKECAEIFSMSPRTWRRKEEPVGTASGTALTPVEFKFLLLLAGEHPDYVLCKRNKKNSDS
GSN
Download Length: 252 bp
>AT87011 NZ_CP024156:37203-37454 [Escherichia coli]
ATGCCAAATGAAAACACACCAGAAAACATTAAACGTCTGCGGCAAAAAATTGGCCTGACACAGAAAGAATGTGCCGAAAT
ATTTAGCATGAGTCCGCGTACCTGGCGTCGCAAAGAAGAACCTGTCGGAACTGCAAGCGGTACAGCACTTACACCAGTAG
AGTTTAAATTTCTTCTGCTTTTAGCTGGAGAACACCCTGATTATGTACTTTGTAAAAGGAATAAAAAGAATTCTGATTCT
GGAAGTAATTAA
ATGCCAAATGAAAACACACCAGAAAACATTAAACGTCTGCGGCAAAAAATTGGCCTGACACAGAAAGAATGTGCCGAAAT
ATTTAGCATGAGTCCGCGTACCTGGCGTCGCAAAGAAGAACCTGTCGGAACTGCAAGCGGTACAGCACTTACACCAGTAG
AGTTTAAATTTCTTCTGCTTTTAGCTGGAGAACACCCTGATTATGTACTTTGTAAAAGGAATAAAAAGAATTCTGATTCT
GGAAGTAATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|