Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2580000..2580526 | Replicon | chromosome |
| Accession | NZ_CP024155 | ||
| Organism | Escherichia coli strain 14EC047 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | CR540_RS13080 | Protein ID | WP_000323025.1 |
| Coordinates | 2580000..2580287 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | CR540_RS13085 | Protein ID | WP_000534858.1 |
| Coordinates | 2580287..2580526 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CR540_RS13035 (2575025) | 2575025..2575240 | - | 216 | WP_000839590.1 | phage lysis protein EssD | - |
| CR540_RS27695 (2575460) | 2575460..2575630 | + | 171 | WP_001405948.1 | putative zinc-binding protein YnfU | - |
| CR540_RS13040 (2575993) | 2575993..2576208 | - | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| CR540_RS13045 (2576509) | 2576509..2576721 | + | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| CR540_RS13050 (2576776) | 2576776..2576865 | + | 90 | WP_120795389.1 | hypothetical protein | - |
| CR540_RS13055 (2577143) | 2577143..2577895 | - | 753 | WP_001047136.1 | antitermination protein | - |
| CR540_RS13060 (2577909) | 2577909..2578958 | - | 1050 | WP_096174476.1 | DUF968 domain-containing protein | - |
| CR540_RS13065 (2578960) | 2578960..2579238 | - | 279 | WP_134894896.1 | hypothetical protein | - |
| CR540_RS13070 (2579305) | 2579305..2579556 | - | 252 | WP_000980993.1 | protein Rem | - |
| CR540_RS13075 (2579773) | 2579773..2579928 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| CR540_RS13080 (2580000) | 2580000..2580287 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| CR540_RS13085 (2580287) | 2580287..2580526 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| CR540_RS13090 (2580551) | 2580551..2580856 | + | 306 | WP_001326990.1 | protein YdfV | - |
| CR540_RS13095 (2581059) | 2581059..2581390 | + | 332 | Protein_2525 | FlxA-like family protein | - |
| CR540_RS27700 (2581826) | 2581826..2581975 | - | 150 | WP_011443592.1 | protein YdfW | - |
| CR540_RS13100 (2582048) | 2582048..2583118 | - | 1071 | Protein_2527 | ISNCY family transposase | - |
| CR540_RS27705 (2583908) | 2583908..2584195 | - | 288 | Protein_2528 | hypothetical protein | - |
| CR540_RS13115 (2584509) | 2584509..2584889 | + | 381 | WP_001171554.1 | transposase | - |
| CR540_RS13120 (2584886) | 2584886..2585233 | + | 348 | WP_000612591.1 | IS66 family insertion sequence element accessory protein TnpB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2545022..2596067 | 51045 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T86999 WP_000323025.1 NZ_CP024155:c2580287-2580000 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T86999 NZ_CP024155:c2580287-2580000 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT86999 WP_000534858.1 NZ_CP024155:c2580526-2580287 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT86999 NZ_CP024155:c2580526-2580287 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|