Detailed information of TA system TA086929

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX(toxin)
• Location: 4276078..4276892
• Replicon: chromosome
• Accession: NZ_CP024141
• Organism: Escherichia coli strain 14EC029

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: CR538_RS22230
• Protein ID: WP_001054376.1
• Coordinates: 4276078..4276335 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: CR538_RS22235
• Protein ID: WP_101968878.1
• Coordinates: 4276347..4276892 (+)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CR538_RS22200	4271366..4272472	+	1107	WP_001309184.1	N-acetylneuraminate epimerase	-
CR538_RS22205	4272537..4273517	+	981	WP_000991438.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
CR538_RS22210	4274100..4275340	-	1241	Protein_4058	helicase YjhR	-
CR538_RS22220	4275456..4275701	+	246	Protein_4059	GNAT family N-acetyltransferase	-
CR538_RS22230	4276078..4276335	+	258	WP_001054376.1	hypothetical protein	Toxin
CR538_RS22235	4276347..4276892	+	546	WP_101968878.1	N-acetyltransferase	Antitoxin
CR538_RS22240	4276948..4277694	+	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
CR538_RS22245	4277863..4278081	+	219	Protein_4063	hypothetical protein	-
CR538_RS30035	4278119..4278235	+	117	Protein_4064	VOC family protein	-
CR538_RS22250	4278480..4279601	+	1122	WP_000010829.1	M42 family metallopeptidase	-
CR538_RS22255	4279598..4279876	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
CR538_RS22260	4279888..4281201	+	1314	WP_000460843.1	galactitol-specific PTS transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimI / fimA / fimE / fimB	4265863..4292582	26719

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T86929 WP_001054376.1 NZ_CP024141:4276078-4276335 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T86929 NZ_CP024141:4276078-4276335 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19914.82 Da
• Isoelectric Point: 6.3277

>AT86929 WP_101968878.1 NZ_CP024141:4276347-4276892 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAGGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT86929 NZ_CP024141:4276347-4276892 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGGCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Structures

Toxin

• AlphaFold DB: S1PA82