Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4375021..4375853 Replicon chromosome
Accession NZ_CP024138
Organism Escherichia coli strain 14EC020

Toxin (Protein)


Gene name yeeV Uniprot ID S1PD64
Locus tag CR537_RS22745 Protein ID WP_000854753.1
Coordinates 4375479..4375853 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag CR537_RS22740 Protein ID WP_001295723.1
Coordinates 4375021..4375389 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CR537_RS22705 4370854..4371534 + 681 WP_001282919.1 WYL domain-containing protein -
CR537_RS22710 4371682..4372359 + 678 WP_001097301.1 hypothetical protein -
CR537_RS22715 4372365..4372598 + 234 WP_001278283.1 DUF905 family protein -
CR537_RS22720 4372688..4373506 + 819 WP_001773857.1 DUF945 domain-containing protein -
CR537_RS22725 4373597..4374082 + 486 WP_000214398.1 antirestriction protein -
CR537_RS22730 4374098..4374574 + 477 WP_001186786.1 RadC family protein -
CR537_RS22735 4374637..4374858 + 222 WP_000692311.1 DUF987 domain-containing protein -
CR537_RS22740 4375021..4375389 + 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CR537_RS22745 4375479..4375853 + 375 WP_000854753.1 TA system toxin CbtA family protein Toxin
CR537_RS22750 4375850..4376338 + 489 WP_000777545.1 hypothetical protein -
CR537_RS22755 4376350..4376547 + 198 WP_000839281.1 DUF957 domain-containing protein -
CR537_RS22760 4376644..4377213 + 570 WP_001560692.1 DUF4942 domain-containing protein -
CR537_RS22770 4377962..4379500 + 1539 WP_001187191.1 lysine decarboxylation/transport transcriptional activator CadC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14005.00 Da        Isoelectric Point: 8.2905

>T86895 WP_000854753.1 NZ_CP024138:4375479-4375853 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

>T86895 NZ_CP024138:4375479-4375853 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT86895 WP_001295723.1 NZ_CP024138:4375021-4375389 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT86895 NZ_CP024138:4375021-4375389 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LVU0

Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References